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10.1016/j.celrep.2015.08.002 http://scihub22266oqcxt.onion/10.1016/j.celrep.2015.08.002 C4578660!4578660 !26321637     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26321637 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Rep 2015 ; 12 (10 ): 1618-30 Nephropedia Template TP {{tp|p=26321637 |t=2015. Splicing-Dependent Trans-synaptic SALM3-LAR-RPTP Interactions Regulate Excitatory Synapse Development and Locomotion |pdf=|usr=}}{{26321637 }} gab.com Text Splicing-Dependent Trans-synaptic SALM3-LAR-RPTP Interactions Regulate Excitatory Synapse Development and Locomotion JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26321637 #FOAvip Synaptic adhesion molecules regulate diverse aspects of synapse development and plasticity. SALM3 is a PSD-95-interacting synaptic adhesion molecule known to induce presynaptic differentiation in contacting axons, but little is known about its presynaptic receptors and in vivo functions. Here, we identify an interaction between SALM3 and LAR family receptor protein tyrosine phosphatases (LAR-RPTPs) that requires the mini-exon B splice insert in LAR-RPTPs. In addition, SALM3-dependent presynaptic differentiation requires all three types of LAR-RPTPs. SALM3 mutant (Salm3(-/-)) mice display markedly reduced excitatory synapse number but normal synaptic plasticity in the hippocampal CA1 region. Salm3(-/-) mice exhibit hypoactivity in both novel and familiar environments but perform normally in learning and memory tests administered. These results suggest that SALM3 regulates excitatory synapse development and locomotion behavior. Twit Text FOAVip Splicing-Dependent Trans-synaptic SALM3-LAR-RPTP Interactions Regulate Excitatory Synapse Development and Locomotion ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26321637 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26321637 #FOAvip English Wikipedia <ref>{{Cite pmid|26321637 }}</ref> Splicing-Dependent Trans-synaptic SALM3-LAR-RPTP Interactions Regulate Excitatory Synapse Development and Locomotion #MMPMID26321637 Li Y ; Zhang P ; Choi TY ; Park SK ; Park H ; Lee EJ ; Lee D ; Roh JD ; Mah W ; Kim R ; Kim Y ; Kwon H ; Bae YC ; Choi SY ; Craig AM ; Kim E Cell Rep 2015[Sep]; 12 (10 ): 1618-30 PMID26321637 show ga Synaptic adhesion molecules regulate diverse aspects of synapse development and plasticity. SALM3 is a PSD-95-interacting synaptic adhesion molecule known to induce presynaptic differentiation in contacting axons, but little is known about its presynaptic receptors and in vivo functions. Here, we identify an interaction between SALM3 and LAR family receptor protein tyrosine phosphatases (LAR-RPTPs) that requires the mini-exon B splice insert in LAR-RPTPs. In addition, SALM3-dependent presynaptic differentiation requires all three types of LAR-RPTPs. SALM3 mutant (Salm3(-/-)) mice display markedly reduced excitatory synapse number but normal synaptic plasticity in the hippocampal CA1 region. Salm3(-/-) mice exhibit hypoactivity in both novel and familiar environments but perform normally in learning and memory tests administered. These results suggest that SALM3 regulates excitatory synapse development and locomotion behavior. |Alternative Splicing [MESH] |Animals [MESH] |Cell Differentiation [MESH] |Excitatory Postsynaptic Potentials [MESH] |Exons [MESH] |Hippocampus/cytology/metabolism [MESH] |Learning [MESH] |Locomotion [MESH] |Membrane Glycoproteins [MESH] |Mice, Knockout [MESH] |Nerve Tissue Proteins [MESH] |Neural Cell Adhesion Molecules/*physiology [MESH] |Neuronal Plasticity [MESH] |Protein Isoforms/physiology [MESH] |Psychomotor Performance [MESH] |RNA Splice Sites [MESH] |Receptor-Like Protein Tyrosine Phosphatases, Class 2/*metabolism [MESH] |Synapses/*physiology [MESH]Splicing-Dependent Trans-synaptic SALM3-LAR-RPTP Interactions Regulate(epmc).pdf DeepDyve Pubget Overpricing