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10.5483/BMBRep.2015.48.6.073 http://scihub22266oqcxt.onion/10.5483/BMBRep.2015.48.6.073 C4578618!4578618!25047444     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMB+Rep 2015 ; 48 (6): 324-9 Nephropedia Template TP {{tp|p=25047444|t=2015. Anticancer activity of CopA3 dimer peptide in human gastric cancer cells |pdf=|usr=}}{{25047444}} gab.com Text Anticancer activity of CopA3 dimer peptide in human gastric cancer cells JO: BMB Rep http://www.kidney.de/pget.php?&tw=1&pmid=25047444 #FOAvip CopA3 is a homodimeric ?-helical peptide derived from coprisin which is a defensin-like antimicrobial peptide that was identified from the dung beetle, Copris tripartitus. CopA3 has been reported to have anticancer activity against leukemia cancer cells. In the present study, we investigated the anticancer activity of CopA3 in human gastric cancer cells. CopA3 reduced cell viability and it was cytotoxic to gastric cancer cells in the MTS and LDH release assay, respectively. CopA3 was shown to induce necrotic cell death of the gastric cancer cells by flow cytometric analysis and acridine orange/ethidium bromide staining. CopA3-induced cell death was mediated by specific interactions with phosphatidylserine, a membrane component of cancer cells. Taken together, these data indicated that CopA3 mainly caused necrosis of gastric cancer cells, probably through interactions with phosphatidylserine, which suggests the potential utility of CopA3 as a cancer therapeutic. [BMB Reports 2015; 48(6): 324-329] Twit Text FOAVip Anticancer activity of CopA3 dimer peptide in human gastric cancer cells ????BMB Rep http://www.kidney.de/pget.php?&tw=1&pmid=25047444 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25047444 #FOAvip English Wikipedia <ref>{{Cite pmid|25047444}}</ref> Anticancer activity of CopA3 dimer peptide in human gastric cancer cells #MMPMID25047444 Lee JH; Kim IW; Kim SH; Yun EY; Nam SH; Ahn MY; Kang DC; Hwang JS BMB Rep 2015[Jun]; 48 (6): 324-9 PMID25047444show ga CopA3 is a homodimeric ?-helical peptide derived from coprisin which is a defensin-like antimicrobial peptide that was identified from the dung beetle, Copris tripartitus. CopA3 has been reported to have anticancer activity against leukemia cancer cells. In the present study, we investigated the anticancer activity of CopA3 in human gastric cancer cells. CopA3 reduced cell viability and it was cytotoxic to gastric cancer cells in the MTS and LDH release assay, respectively. CopA3 was shown to induce necrotic cell death of the gastric cancer cells by flow cytometric analysis and acridine orange/ethidium bromide staining. CopA3-induced cell death was mediated by specific interactions with phosphatidylserine, a membrane component of cancer cells. Taken together, these data indicated that CopA3 mainly caused necrosis of gastric cancer cells, probably through interactions with phosphatidylserine, which suggests the potential utility of CopA3 as a cancer therapeutic. [BMB Reports 2015; 48(6): 324-329] äAnticancer activity of CopA3 dimer peptide in human gastric cancer cel(epmc).pdf DeepDyve Pubget Overpricing