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10.5483/BMBRep.2015.48.6.080 http://scihub22266oqcxt.onion/10.5483/BMBRep.2015.48.6.080 C4578614!4578614!25936780     free     free     free       BMB+Rep 2015 ; 48 (6): 301-2 Nephropedia Template TP {{tp|p=25936780|t=2015. NDRG3-mediated lactate signaling in hypoxia |pdf=|usr=}}{{25936780}} gab.com Text NDRG3-mediated lactate signaling in hypoxia JO: BMB Rep http://www.kidney.de/pget.php?&tw=1&pmid=25936780 #FOAvip Hypoxia is associated with many pathological conditions as well as the normal physiology of metazoans. We identified a lactate-dependent signaling pathway in hypoxia, mediated by the oxygen- and lactate-regulated protein NDRG family member 3 (NDRG3). Oxygen negatively regulates NDRG3 expression at the protein level via the PHD2/VHL system, whereas lactate, produced in excess under prolonged hypoxia, blocks its proteasomal degradation by binding to NDRG3. We also found that the stabilized NDRG3 protein promotes angiogenesis and cell growth under hypoxia by activating the Raf-ERK pathway. Inhibiting cellular lactate production abolishes NDRG3-mediated hypoxia responses. The NDRG3-Raf-ERK axis therefore provides the genetic basis for lactate-induced hypoxia signaling, which can be exploited for the development of therapies targeting hypoxia-induced diseases in addition to advancing our understanding of the normal physiology of hypoxia responses. [BMB Reports 2015; 48(6): 301-302] Twit Text FOAVip NDRG3-mediated lactate signaling in hypoxia ????BMB Rep http://www.kidney.de/pget.php?&tw=1&pmid=25936780 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25936780 #FOAvip English Wikipedia <ref>{{Cite pmid|25936780}}</ref> NDRG3-mediated lactate signaling in hypoxia #MMPMID25936780 Park KC; Lee DC; Yeom YI BMB Rep 2015[Jun]; 48 (6): 301-2 PMID25936780show ga Hypoxia is associated with many pathological conditions as well as the normal physiology of metazoans. We identified a lactate-dependent signaling pathway in hypoxia, mediated by the oxygen- and lactate-regulated protein NDRG family member 3 (NDRG3). Oxygen negatively regulates NDRG3 expression at the protein level via the PHD2/VHL system, whereas lactate, produced in excess under prolonged hypoxia, blocks its proteasomal degradation by binding to NDRG3. We also found that the stabilized NDRG3 protein promotes angiogenesis and cell growth under hypoxia by activating the Raf-ERK pathway. Inhibiting cellular lactate production abolishes NDRG3-mediated hypoxia responses. The NDRG3-Raf-ERK axis therefore provides the genetic basis for lactate-induced hypoxia signaling, which can be exploited for the development of therapies targeting hypoxia-induced diseases in addition to advancing our understanding of the normal physiology of hypoxia responses. [BMB Reports 2015; 48(6): 301-302] äNDRG3-mediated lactate signaling in hypoxia (epmc).pdf DeepDyve Pubget Overpricing