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10.5483/BMBRep.2015.48.5.021 http://scihub22266oqcxt.onion/10.5483/BMBRep.2015.48.5.021 C4578565!4578565!25787993     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMB+Rep 2015 ; 48 (5): 266-70 Nephropedia Template TP {{tp|p=25787993|t=2015. Isocitrate dehydrogenase mutations: new opportunities for translational research |pdf=|usr=}}{{25787993}} gab.com Text Isocitrate dehydrogenase mutations: new opportunities for translational research JO: BMB Rep http://www.kidney.de/pget.php?&tw=1&pmid=25787993 #FOAvip Over the last decade, comprehensive genome-wide sequencing studies have enabled us to find out unexpected genetic alterations of metabolism in cancer. An example is the identification of arginine missense mutations of isocitrate dehydrogenases-1 and -2 (IDH1/2) in glioma, acute myeloid leukemia (AML), chondrosarcomas, and cholangiocarcinoma. These alterations are closely associated with the production of a new stereospecific metabolite, (R)-2-hydroxyglutarate (R-2HG). A large number of follow-up studies have been performed to address the molecular mechanisms of IDH1/2 mutations underlying how these events contribute to malignant transformation. In the meanwhile, the development of selective mutant IDH1/2 chemical inhibitors is being actively pursued in the scientific community and pharmaceutical industry. The present review article briefly discusses the important findings that highlight the molecular mechanisms of IDH1/2 mutations in cancer and provides a current status for development of selective mutant IDH1/2 chemical inhibitors. [BMB Reports 2015; 48(5): 266-270] Twit Text FOAVip Isocitrate dehydrogenase mutations: new opportunities for translational research ????BMB Rep http://www.kidney.de/pget.php?&tw=1&pmid=25787993 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25787993 #FOAvip English Wikipedia <ref>{{Cite pmid|25787993}}</ref> Isocitrate dehydrogenase mutations: new opportunities for translational research #MMPMID25787993 Keum YS; Choi BY BMB Rep 2015[May]; 48 (5): 266-70 PMID25787993show ga Over the last decade, comprehensive genome-wide sequencing studies have enabled us to find out unexpected genetic alterations of metabolism in cancer. An example is the identification of arginine missense mutations of isocitrate dehydrogenases-1 and -2 (IDH1/2) in glioma, acute myeloid leukemia (AML), chondrosarcomas, and cholangiocarcinoma. These alterations are closely associated with the production of a new stereospecific metabolite, (R)-2-hydroxyglutarate (R-2HG). A large number of follow-up studies have been performed to address the molecular mechanisms of IDH1/2 mutations underlying how these events contribute to malignant transformation. In the meanwhile, the development of selective mutant IDH1/2 chemical inhibitors is being actively pursued in the scientific community and pharmaceutical industry. The present review article briefly discusses the important findings that highlight the molecular mechanisms of IDH1/2 mutations in cancer and provides a current status for development of selective mutant IDH1/2 chemical inhibitors. [BMB Reports 2015; 48(5): 266-270] äIsocitrate dehydrogenase mutations: new opportunities for translationa(epmc).pdf DeepDyve Pubget Overpricing