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10.4161/21592527.2014.967616 http://scihub22266oqcxt.onion/10.4161/21592527.2014.967616 C4578555!4578555!25482335     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomatter 2014 ; 4 (ä): ä Nephropedia Template TP {{tp|p=25482335|t=2014. Comparison of the reaction of bone-derived cells to enhanced MgCl2-salt concentrations |pdf=|usr=}}{{25482335}} gab.com Text Comparison of the reaction of bone-derived cells to enhanced MgCl2-salt concentrations JO: Biomatter http://www.kidney.de/pget.php?&tw=1&pmid=25482335 #FOAvip Magnesium-based implants exhibit various advantages such as biodegradability and potential for enhanced in vivo bone formation. However, the cellular mechanisms behind this possible osteoconductivity remain unclear. To determine whether high local magnesium concentrations can be osteoconductive and exclude other environmental factors that occur during the degradation of magnesium implants, magnesium salt (MgCl2) was used as a model system. Because cell lines are preferred targets in studies of non-degradable implant materials, we performed a comparative study of 3 osteosarcoma-derived cell lines (MG63, SaoS2 and U2OS) with primary human osteoblasts. The correlation among cell count, viability, cell size and several MgCl2 concentrations was used to examine the influence of magnesium on proliferation in vitro. Moreover, bone metabolism alterations during proliferation were investigated by analyzing the expression of genes involved in osteogenesis. It was observed that for all cell types, the cell count decreases at concentrations above 10 mM MgCl2. However, detailed analysis showed that MgCl2 has a relevant but very diverse influence on proliferation and bone metabolism, depending on the cell type. Only for primary cells was a clear stimulating effect observed. Therefore, reliable results demonstrating the osteoconductivity of magnesium implants can only be achieved with primary osteoblasts. Twit Text FOAVip Comparison of the reaction of bone-derived cells to enhanced MgCl2-salt concentrations ????Biomatter http://www.kidney.de/pget.php?&tw=1&pmid=25482335 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25482335 #FOAvip English Wikipedia <ref>{{Cite pmid|25482335}}</ref> Comparison of the reaction of bone-derived cells to enhanced MgCl2-salt concentrations #MMPMID25482335 Burmester A; Luthringer B; Willumeit R; Feyerabend F Biomatter 2014[]; 4 (ä): ä PMID25482335show ga Magnesium-based implants exhibit various advantages such as biodegradability and potential for enhanced in vivo bone formation. However, the cellular mechanisms behind this possible osteoconductivity remain unclear. To determine whether high local magnesium concentrations can be osteoconductive and exclude other environmental factors that occur during the degradation of magnesium implants, magnesium salt (MgCl2) was used as a model system. Because cell lines are preferred targets in studies of non-degradable implant materials, we performed a comparative study of 3 osteosarcoma-derived cell lines (MG63, SaoS2 and U2OS) with primary human osteoblasts. The correlation among cell count, viability, cell size and several MgCl2 concentrations was used to examine the influence of magnesium on proliferation in vitro. Moreover, bone metabolism alterations during proliferation were investigated by analyzing the expression of genes involved in osteogenesis. It was observed that for all cell types, the cell count decreases at concentrations above 10 mM MgCl2. However, detailed analysis showed that MgCl2 has a relevant but very diverse influence on proliferation and bone metabolism, depending on the cell type. Only for primary cells was a clear stimulating effect observed. Therefore, reliable results demonstrating the osteoconductivity of magnesium implants can only be achieved with primary osteoblasts. äComparison of the reaction of bone-derived cells to enhanced MgCl2-sal(epmc).pdf DeepDyve Pubget Overpricing