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10.1038/nm.2392 http://scihub22266oqcxt.onion/10.1038/nm.2392 C4578312!4578312!21804542     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Med 2011 ; 17 (8): 944-51 Nephropedia Template TP {{tp|p=21804542|t=2011. Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11 |pdf=|usr=}}{{21804542}} gab.com Text Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11 JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=21804542 #FOAvip PICT1 (also known as GLTSCR2) is considered a tumor suppressor because it stabilizes phosphatase and tensin homolog (PTEN), but individuals with oligodendrogliomas lacking chromosome 19q13, where PICT1 is located, have better prognoses than other oligodendroglioma patients. To clarify the function of PICT1, we generated Pict1-deficient mice and embryonic stem (ES) cells. Pict1 is a nucleolar protein essential for embryogenesis and ES cell survival. Even without DNA damage, Pict1 loss led to p53-dependent arrest of cell cycle phase G1 and apoptosis. Pict1-deficient cells accumulated p53, owing to impaired Mdm2 function. Pict1 binds Rpl11, and Rpl11 is released from nucleoli in the absence of Pict1. In Pict1-deficient cells, increased binding of Rpl11 to Mdm2 blocks Mdm2-mediated ubiquitination of p53. In human cancer, individuals whose tumors express less PICT1 have better prognoses. When PICT1 is depleted in tumor cells with intact P53 signaling, the cells grow more slowly and accumulate P53. Thus, PICT1 is a potent regulator of the MDM2-P53 pathway and promotes tumor progression by retaining RPL11 in the nucleolus Twit Text FOAVip Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11 ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=21804542 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21804542 #FOAvip English Wikipedia <ref>{{Cite pmid|21804542}}</ref> Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11 #MMPMID21804542 Sasaki M; Kawahara K; Nishio M; Mimori K; Kogo R; Hamada K; Itoh B; Wang J; Komatsu Y; Yang YR; Hikasa H; Horie Y; Yamashita T; Kamijo T; Zhang Y; Zhu Y; Prives C; Nakano T; Mak TW; Sasaki T; Maehama T; Mori M; Suzuki A Nat Med 2011[Aug]; 17 (8): 944-51 PMID21804542show ga PICT1 (also known as GLTSCR2) is considered a tumor suppressor because it stabilizes phosphatase and tensin homolog (PTEN), but individuals with oligodendrogliomas lacking chromosome 19q13, where PICT1 is located, have better prognoses than other oligodendroglioma patients. To clarify the function of PICT1, we generated Pict1-deficient mice and embryonic stem (ES) cells. Pict1 is a nucleolar protein essential for embryogenesis and ES cell survival. Even without DNA damage, Pict1 loss led to p53-dependent arrest of cell cycle phase G1 and apoptosis. Pict1-deficient cells accumulated p53, owing to impaired Mdm2 function. Pict1 binds Rpl11, and Rpl11 is released from nucleoli in the absence of Pict1. In Pict1-deficient cells, increased binding of Rpl11 to Mdm2 blocks Mdm2-mediated ubiquitination of p53. In human cancer, individuals whose tumors express less PICT1 have better prognoses. When PICT1 is depleted in tumor cells with intact P53 signaling, the cells grow more slowly and accumulate P53. Thus, PICT1 is a potent regulator of the MDM2-P53 pathway and promotes tumor progression by retaining RPL11 in the nucleolus äRegulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucle(epmc).pdf DeepDyve Pubget Overpricing