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10.3904/kjim.2015.30.5.602

http://scihub22266oqcxt.onion/10.3904/kjim.2015.30.5.602
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suck abstract from ncbi


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pmid26354054      Korean+J+Intern+Med 2015 ; 30 (5): 602-9
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  • Oral udenafil and aceclofenac for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis in high-risk patients: a randomized multicenter study #MMPMID26354054
  • Lee TY; Choi JS; Oh HC; Song TJ; Do JH; Cheon YK
  • Korean J Intern Med 2015[Sep]; 30 (5): 602-9 PMID26354054show ga
  • Background/Aims:: Acute pancreatitis is a common complication of endoscopic retrograde cholangiopancreatography (ERCP). Combination therapy w ith ora l udenafil and aceclofenac may reduce the occurrence of post-ERCP pancreatitis by targeting different pathophysiological mechanisms. We investigated whether combining udenafil and aceclofenac reduced the rates of post-ERCP pancreatitis. Methods:: A prospective, randomized, double-blind, placebo-controlled, multicenter study was conducted in four academic medical centers. Between January 2012 and June 2013, a total of 216 patients who underwent ERCP were analyzed for the occurrence of post-ERCP pancreatitis. Patients were determined to be at high risk for pancreatitis based on validated patient and procedure-related risk factors. Results:: Demographic features, indications for ERCP, and therapeutic procedures were similar in each group. There were no significant differences in the rate (15.8% [17/107] vs. 16.5% [18/109], p = 0.901) and severity of post-ERCP pancreatitis between the udenafil/aceclofenac and placebo groups. One patient in each group developed severe pancreatitis. Multivariate analyses indicated that suspected dysfunction of the sphincter of Oddi and endoscopic papillary balloon dilation without sphincterotomy were associated with post-ERCP pancreatitis. Conclusions:: Combination therapy with udenafil and aceclofenac is not effective for the prevention of post-ERCP pancreatitis.
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