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10.1084/jem.20150585

http://scihub22266oqcxt.onion/10.1084/jem.20150585
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C4577851!4577851!26371186
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suck abstract from ncbi


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pmid26371186      J+Exp+Med 2015 ; 212 (10): 1663-77
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  • Altered BCR and TLR signals promote enhanced positive selection of autoreactive transitional B cells in Wiskott-Aldrich syndrome #MMPMID26371186
  • Kolhatkar NS; Brahmandam A; Thouvenel CD; Becker-Herman S; Jacobs HM; Schwartz MA; Allenspach EJ; Khim S; Panigrahi AK; Luning Prak ET; Thrasher AJ; Notarangelo LD; Candotti F; Torgerson TR; Sanz I; Rawlings DJ
  • J Exp Med 2015[Sep]; 212 (10): 1663-77 PMID26371186show ga
  • Kolhatkar et al. report that altered BCR and TLR signaling orchestrates increased positive selection of transitional B cells expressing low-affinity self-reactive BCRs, leading to their enrichment within the naive B cell compartment. These findings have important implications to understand events that promote altered B cell selection in both Wiskott-Aldrich syndrome patients and in other autoimmune-prone individuals.
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