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10.1084/jem.20141271 http://scihub22266oqcxt.onion/10.1084/jem.20141271 C4577850!4577850 !26324445     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26324445 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Exp+Med 2015 ; 212 (10 ): 1693-708 Nephropedia Template TP {{tp|p=26324445 |t=2015. Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation |pdf=|usr=}}{{26324445 }} gab.com Text Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=26324445 #FOAvip B cell antigen receptor (BCR) signaling is critical for B cell development and activation. Using mass spectrometry, we identified a protein kinase D-interacting substrate of 220 kD (Kidins220)/ankyrin repeat-rich membrane-spanning protein (ARMS) as a novel interaction partner of resting and stimulated BCR. Upon BCR stimulation, the interaction increases in a Src kinase-independent manner. By knocking down Kidins220 in a B cell line and generating a conditional B cell-specific Kidins220 knockout (B-KO) mouse strain, we show that Kidins220 couples the BCR to PLC?2, Ca(2+), and extracellular signal-regulated kinase (Erk) signaling. Consequently, BCR-mediated B cell activation was reduced in vitro and in vivo upon Kidins220 deletion. Furthermore, B cell development was impaired at stages where pre-BCR or BCR signaling is required. Most strikingly, ? light chain-positive B cells were reduced sixfold in the B-KO mice, genetically placing Kidins220 in the PLC?2 pathway. Thus, our data indicate that Kidins220 positively regulates pre-BCR and BCR functioning. Twit Text FOAVip Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=26324445 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26324445 #FOAvip English Wikipedia <ref>{{Cite pmid|26324445 }}</ref> Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation #MMPMID26324445 Fiala GJ ; Janowska I ; Prutek F ; Hobeika E ; Satapathy A ; Sprenger A ; Plum T ; Seidl M ; Dengjel J ; Reth M ; Cesca F ; Brummer T ; Minguet S ; Schamel WW J Exp Med 2015[Sep]; 212 (10 ): 1693-708 PMID26324445 show ga B cell antigen receptor (BCR) signaling is critical for B cell development and activation. Using mass spectrometry, we identified a protein kinase D-interacting substrate of 220 kD (Kidins220)/ankyrin repeat-rich membrane-spanning protein (ARMS) as a novel interaction partner of resting and stimulated BCR. Upon BCR stimulation, the interaction increases in a Src kinase-independent manner. By knocking down Kidins220 in a B cell line and generating a conditional B cell-specific Kidins220 knockout (B-KO) mouse strain, we show that Kidins220 couples the BCR to PLC?2, Ca(2+), and extracellular signal-regulated kinase (Erk) signaling. Consequently, BCR-mediated B cell activation was reduced in vitro and in vivo upon Kidins220 deletion. Furthermore, B cell development was impaired at stages where pre-BCR or BCR signaling is required. Most strikingly, ? light chain-positive B cells were reduced sixfold in the B-KO mice, genetically placing Kidins220 in the PLC?2 pathway. Thus, our data indicate that Kidins220 positively regulates pre-BCR and BCR functioning. |Animals [MESH] |B-Lymphocytes/immunology/*physiology [MESH] |Bone Marrow Cells/metabolism [MESH] |Calcium/metabolism [MESH] |Immunoglobulin D/metabolism [MESH] |Immunoglobulin M/metabolism [MESH] |Lymphocyte Activation [MESH] |Membrane Proteins/genetics/*metabolism [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Mice, Transgenic [MESH] |Phospholipase C gamma/metabolism [MESH] |Receptors, Antigen, B-Cell/*metabolism [MESH]Kidins220/ARMS binds to the B cell antigen receptor and regulates B ce(epmc).pdf DeepDyve Pubget Overpricing