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10.1084/jem.20141831 http://scihub22266oqcxt.onion/10.1084/jem.20141831 C4577836!4577836 !26371187     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26371187 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Exp+Med 2015 ; 212 (10 ): 1513-28 Nephropedia Template TP {{tp|p=26371187 |t=2015. Epithelial-intrinsic IKK? expression regulates group 3 innate lymphoid cell responses and antibacterial immunity |pdf=|usr=}}{{26371187 }} gab.com Text Epithelial-intrinsic IKK expression regulates group 3 innate lymphoid cell responses and antibacterial immunity JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=26371187 #FOAvip Innate lymphoid cells (ILCs) are critical for maintaining epithelial barrier integrity at mucosal surfaces; however, the tissue-specific factors that regulate ILC responses remain poorly characterized. Using mice with intestinal epithelial cell (IEC)-specific deletions in either inhibitor of ?B kinase (IKK)? or IKK?, two critical regulators of NF?B activation, we demonstrate that IEC-intrinsic IKK? expression selectively regulates group 3 ILC (ILC3)-dependent antibacterial immunity in the intestine. Although IKK?(?IEC) mice efficiently controlled Citrobacter rodentium infection, IKK?(?IEC) mice exhibited severe intestinal inflammation, increased bacterial dissemination to peripheral organs, and increased host mortality. Consistent with weakened innate immunity to C. rodentium, IKK?(?IEC) mice displayed impaired IL-22 production by ROR?t(+) ILC3s, and therapeutic delivery of rIL-22 or transfer of sort-purified IL-22-competent ILCs from control mice could protect IKK?(?IEC) mice from C. rodentium-induced morbidity. Defective ILC3 responses in IKK?(?IEC) mice were associated with overproduction of thymic stromal lymphopoietin (TSLP) by IECs, which negatively regulated IL-22 production by ILC3s and impaired innate immunity to C. rodentium. IEC-intrinsic IKK? expression was similarly critical for regulation of intestinal inflammation after chemically induced intestinal damage and colitis. Collectively, these data identify a previously unrecognized role for epithelial cell-intrinsic IKK? expression and TSLP in regulating ILC3 responses required to maintain intestinal barrier immunity. Twit Text FOAVip Epithelial-intrinsic IKK expression regulates group 3 innate lymphoid cell responses and antibacterial immunity ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=26371187 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26371187 #FOAvip English Wikipedia <ref>{{Cite pmid|26371187 }}</ref> Epithelial-intrinsic IKK? expression regulates group 3 innate lymphoid cell responses and antibacterial immunity #MMPMID26371187 Giacomin PR ; Moy RH ; Noti M ; Osborne LC ; Siracusa MC ; Alenghat T ; Liu B ; McCorkell KA ; Troy AE ; Rak GD ; Hu Y ; May MJ ; Ma HL ; Fouser LA ; Sonnenberg GF ; Artis D J Exp Med 2015[Sep]; 212 (10 ): 1513-28 PMID26371187 show ga Innate lymphoid cells (ILCs) are critical for maintaining epithelial barrier integrity at mucosal surfaces; however, the tissue-specific factors that regulate ILC responses remain poorly characterized. Using mice with intestinal epithelial cell (IEC)-specific deletions in either inhibitor of ?B kinase (IKK)? or IKK?, two critical regulators of NF?B activation, we demonstrate that IEC-intrinsic IKK? expression selectively regulates group 3 ILC (ILC3)-dependent antibacterial immunity in the intestine. Although IKK?(?IEC) mice efficiently controlled Citrobacter rodentium infection, IKK?(?IEC) mice exhibited severe intestinal inflammation, increased bacterial dissemination to peripheral organs, and increased host mortality. Consistent with weakened innate immunity to C. rodentium, IKK?(?IEC) mice displayed impaired IL-22 production by ROR?t(+) ILC3s, and therapeutic delivery of rIL-22 or transfer of sort-purified IL-22-competent ILCs from control mice could protect IKK?(?IEC) mice from C. rodentium-induced morbidity. Defective ILC3 responses in IKK?(?IEC) mice were associated with overproduction of thymic stromal lymphopoietin (TSLP) by IECs, which negatively regulated IL-22 production by ILC3s and impaired innate immunity to C. rodentium. IEC-intrinsic IKK? expression was similarly critical for regulation of intestinal inflammation after chemically induced intestinal damage and colitis. Collectively, these data identify a previously unrecognized role for epithelial cell-intrinsic IKK? expression and TSLP in regulating ILC3 responses required to maintain intestinal barrier immunity. |Animals [MESH] |Citrobacter rodentium/pathogenicity [MESH] |Colitis/immunology/pathology [MESH] |Colon/immunology/metabolism/microbiology [MESH] |Cytokines/metabolism [MESH] |Enterobacteriaceae Infections/immunology/mortality [MESH] |Epithelial Cells/metabolism [MESH] |Female [MESH] |I-kappa B Kinase/genetics/immunology/*metabolism [MESH] |Immunity, Innate/*immunology [MESH] |Interleukin-22 [MESH] |Interleukins/genetics/metabolism/pharmacology [MESH] |Lymphocytes/*immunology/microbiology [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |Mice, Mutant Strains [MESH] |Recombinant Proteins/genetics/pharmacology [MESH]Epithelial-intrinsic IKK? expression regulates group 3 innate lymphoid(epmc).pdf DeepDyve Pubget Overpricing