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10.1084/jem.20140654

http://scihub22266oqcxt.onion/10.1084/jem.20140654
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C4577833!4577833!26324446
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suck abstract from ncbi


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pmid26324446      J+Exp+Med 2015 ; 212 (10): 1725-38
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  • NOS1-derived nitric oxide promotes NF-?B transcriptional activity through inhibition of suppressor of cytokine signaling-1 #MMPMID26324446
  • Baig MS; Zaichick SV; Mao M; de Abreu AL; Bakhshi FR; Hart PC; Saqib U; Deng J; Chatterjee S; Block ML; Vogel SM; Malik AB; Consolaro ME; Christman JW; Minshall RD; Gantner BN; Bonini MG
  • J Exp Med 2015[Sep]; 212 (10): 1725-38 PMID26324446show ga
  • NOS1?/? mice show reduced inflammatory responses and tissue damage in experimental sepsis models. Baig et al show that NOS1-derived NO production in macrophages leads to proteolysis of SOCS1 to alleviate its repression of NFkB transcriptional activity in response to TLR4-mediated responses.
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