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10.1016/j.tips.2015.06.002 http://scihub22266oqcxt.onion/10.1016/j.tips.2015.06.002 C4577653!4577653 !26143239     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26143239 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Trends+Pharmacol+Sci 2015 ; 36 (9 ): 560-7 Nephropedia Template TP {{tp|p=26143239 |t=2015. Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system |pdf=|usr=}}{{26143239 }} gab.com Text Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system JO: Trends Pharmacol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26143239 #FOAvip Apelin and its G protein-coupled receptor (GPCR) have emerged as a key signalling pathway in the cardiovascular system. The peptide is a potent inotropic agent and vasodilator. Remarkably, a peptide, Elabela/Toddler, that has little sequence similarity to apelin, has been proposed as a second endogenous apelin receptor ligand and is encoded by a gene from a region of the genome previously classified as 'non-coding'. Apelin is downregulated in pulmonary arterial hypertension and heart failure. To replace the missing endogenous peptide, 'biased' apelin agonists have been designed that preferentially activate G protein pathways, resulting in reduced ?-arrestin recruitment and receptor internalisation, with the additional benefit of attenuating detrimental ?-arrestin signalling. Proof-of-concept studies support the clinical potential for apelin receptor biased agonists. Twit Text FOAVip Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system ????Trends Pharmacol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26143239 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26143239 #FOAvip English Wikipedia <ref>{{Cite pmid|26143239 }}</ref> Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system #MMPMID26143239 Yang P ; Maguire JJ ; Davenport AP Trends Pharmacol Sci 2015[Sep]; 36 (9 ): 560-7 PMID26143239 show ga Apelin and its G protein-coupled receptor (GPCR) have emerged as a key signalling pathway in the cardiovascular system. The peptide is a potent inotropic agent and vasodilator. Remarkably, a peptide, Elabela/Toddler, that has little sequence similarity to apelin, has been proposed as a second endogenous apelin receptor ligand and is encoded by a gene from a region of the genome previously classified as 'non-coding'. Apelin is downregulated in pulmonary arterial hypertension and heart failure. To replace the missing endogenous peptide, 'biased' apelin agonists have been designed that preferentially activate G protein pathways, resulting in reduced ?-arrestin recruitment and receptor internalisation, with the additional benefit of attenuating detrimental ?-arrestin signalling. Proof-of-concept studies support the clinical potential for apelin receptor biased agonists. |Amino Acid Sequence [MESH] |Animals [MESH] |Cardiovascular Diseases/*drug therapy/metabolism [MESH] |Humans [MESH] |Intercellular Signaling Peptides and Proteins/chemistry/*pharmacology/therapeutic use [MESH] |Molecular Sequence Data [MESH] |Peptide Hormones/chemistry/*pharmacology/therapeutic use [MESH]Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agen(epmc).pdf DeepDyve Pubget Overpricing