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2015 ; 2015
(ä): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
From past sailors eras to the present day: scurvy as a surprising manifestation
of an uncommon gastrointestinal disease
#MMPMID26376699
Branquinho DF
; Pinto-Gouveia M
; Mendes S
; Sofia C
BMJ Case Rep
2015[Sep]; 2015
(ä): ä PMID26376699
show ga
A 45-year-old man presented with follicular exanthema in his lower limbs,
alternating bowel habits and significant weight loss. His medical history
included seronegative arthritis, bipolar disease and an inconclusive diagnostic
laparoscopy. Diagnostic work up revealed microcytic anaemia and multivitamin
deficiency. Skin biopsy of the exanthema suggested scurvy. Owing to these signs
of malabsorption, upper endoscopy with duodenal biopsies was performed,
exhibiting villous atrophy and extensive periodic acid-Schiff-positive material
in the lamina propria, therefore diagnosing Whipple's disease (WD). After
starting treatment with ceftriaxone and co-trimoxazole, an impressive recovery
was noted, as the wide spectrum of malabsorption signs quickly disappeared. After
a year of antibiotics, articular and cutaneous manifestations improved, allowing
the patient to stop taking corticosteroids and antidepressants. This truly
unusual presentation reflects the multisystemic nature of WD, often leading to
misdiagnosis of other entities. Scurvy is a rare finding in developed countries,
but its presence should raise suspicion for small bowel disease.