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10.1007/s10157-015-1106-2 http://scihub22266oqcxt.onion/10.1007/s10157-015-1106-2 C4577308!4577308 !25795029     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25795029 &cmd=llinks): Failed to open stream: HTTP request failed! 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Anti-albuminuric effects of spironolactone in patients with type 2 diabetic nephropathy: a multicenter, randomized clinical trial |pdf=|usr=}}{{25795029 }} gab.com Text Anti-albuminuric effects of spironolactone in patients with type 2 diabetic nephropathy: a multicenter, randomized clinical trial JO: Clin Exp Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=25795029 #FOAvip BACKGROUND: Several studies have demonstrated that spironolactone has an anti-albuminuric property in diabetic nephropathy. As an adverse event, spironolactone often induces the elevation of creatinine levels with hypotension and hyperkalemia. Therefore, we aimed to evaluate the efficacy and safety of spironolactone in Japanese patients with type 2 diabetes treated with either angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. METHODS: Fifty-two Japanese patients with diabetic nephropathy and albuminuria (100 mg/gCr-2000 mg/gCr) treated with renin-angiotensin system (RAS) blockade were enrolled in a prospective, randomized, open-label study. The patients were subjected to add-on treatment with spironolactone 25 mg once daily and compared with matched controls for 8 weeks. The primary outcome was a reduction in the rate of albuminuria at 8 weeks compared with the baseline value. This study was registered with UMIN Clinical Trials Registry (000008016). RESULTS: Albuminuria was reduced by 33 % (95 % confidence interval: 22-54; P = 0.0002) at 8 weeks with spironolactone. In the spironolactone group, blood pressure tended to lower and the estimated glomerular filtration rate (eGFR) was significantly decreased compared to those in the control group. When adjusted by systolic blood pressure and eGFR, spironolactone treatment still showed a significant effect on albuminuria reduction in a linear mixed model (coefficient ± standard error; 514.4 ± 137.6 mg/gCr, P < 0.0005). No patient was excluded from the study because of hyperkalemia. CONCLUSIONS: Spironolactone reduced albuminuria along with conventional RAS inhibitors in patients with diabetic nephropathy. Our study suggests that spironolactone exerts anti-albuminuric effects independent of systemic hemodynamic alterations. Twit Text FOAVip Anti-albuminuric effects of spironolactone in patients with type 2 diabetic nephropathy: a multicenter, randomized clinical trial ????Clin Exp Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=25795029 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25795029 #FOAvip English Wikipedia <ref>{{Cite pmid|25795029 }}</ref> Anti-albuminuric effects of spironolactone in patients with type 2 diabetic nephropathy: a multicenter, randomized clinical trial #MMPMID25795029 Kato S ; Maruyama S ; Makino H ; Wada J ; Ogawa D ; Uzu T ; Araki H ; Koya D ; Kanasaki K ; Oiso Y ; Goto M ; Nishiyama A ; Kobori H ; Imai E ; Ando M ; Matsuo S Clin Exp Nephrol 2015[Dec]; 19 (6 ): 1098-106 PMID25795029 show ga BACKGROUND: Several studies have demonstrated that spironolactone has an anti-albuminuric property in diabetic nephropathy. As an adverse event, spironolactone often induces the elevation of creatinine levels with hypotension and hyperkalemia. Therefore, we aimed to evaluate the efficacy and safety of spironolactone in Japanese patients with type 2 diabetes treated with either angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. METHODS: Fifty-two Japanese patients with diabetic nephropathy and albuminuria (100 mg/gCr-2000 mg/gCr) treated with renin-angiotensin system (RAS) blockade were enrolled in a prospective, randomized, open-label study. The patients were subjected to add-on treatment with spironolactone 25 mg once daily and compared with matched controls for 8 weeks. The primary outcome was a reduction in the rate of albuminuria at 8 weeks compared with the baseline value. This study was registered with UMIN Clinical Trials Registry (000008016). RESULTS: Albuminuria was reduced by 33 % (95 % confidence interval: 22-54; P = 0.0002) at 8 weeks with spironolactone. In the spironolactone group, blood pressure tended to lower and the estimated glomerular filtration rate (eGFR) was significantly decreased compared to those in the control group. When adjusted by systolic blood pressure and eGFR, spironolactone treatment still showed a significant effect on albuminuria reduction in a linear mixed model (coefficient ± standard error; 514.4 ± 137.6 mg/gCr, P < 0.0005). No patient was excluded from the study because of hyperkalemia. CONCLUSIONS: Spironolactone reduced albuminuria along with conventional RAS inhibitors in patients with diabetic nephropathy. Our study suggests that spironolactone exerts anti-albuminuric effects independent of systemic hemodynamic alterations. |Adult [MESH] |Aged [MESH] |Albuminuria/complications/*drug therapy [MESH] |Aldosterone/blood [MESH] |Asian People [MESH] |Blood Pressure/drug effects [MESH] |Diabetes Mellitus, Type 2/*complications/urine [MESH] |Diabetic Nephropathies/*drug therapy/*urine [MESH] |Female [MESH] |Glomerular Filtration Rate/drug effects [MESH] |Humans [MESH] |Male [MESH] |Middle Aged [MESH] |Mineralocorticoid Receptor Antagonists/adverse effects/*therapeutic use [MESH] |Prospective Studies [MESH] |Spironolactone/adverse effects/*therapeutic use [MESH]Anti-albuminuric effects of spironolactone in patients with type 2 dia(epmc).pdf DeepDyve Pubget Overpricing