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10.1016/j.bbrc.2015.01.059

http://scihub22266oqcxt.onion/10.1016/j.bbrc.2015.01.059
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C4577281!4577281!25623531
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suck abstract from ncbi


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pmid25623531      Biochem+Biophys+Res+Commun 2015 ; 457 (4): 718-22
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  • Zonarol, a sesquiterpene from the brown algae Dictyopteris undulata, provides neuroprotection by activating the Nrf2/ARE pathway #MMPMID25623531
  • Shimizu H; Koyama T; Yamada S; Lipton SA; Satoh T
  • Biochem Biophys Res Commun 2015[Feb]; 457 (4): 718-22 PMID25623531show ga
  • Seaweed-origin electrophilic compounds are proposed as a class of neuroprotective compounds that provide neuroprotection through activation of the Nrf2/ARE pathway. Electrophilic hydroquinones are of particular interest due to their ability to become electrophilic quinones upon auto-oxidation. Although many marine plants produce a variety of electrophilic compounds, the detailed mechanism of action of these compounds remain unknown. Here, we focused on the neuroprotective effects of zonarol (ZO), a para-hydroquinone-type pro-electrophilic compound from the brown algae Dictyopteris undulata. We show that ZO activates the Nrf2/ARE pathway, induces phase-2 enzymes, and protects neuronal cells from oxidative stress. ZO is the first example of a neuroprotective pro-electrophilic compound obtained from brown algae.
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