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http://scihub22266oqcxt.onion/ C4577232!4577232!25862839     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Anticancer+Res 2015 ; 35 (4): 1861-6 Nephropedia Template TP {{tp|p=25862839|t=2015. Clinical Significance of Kallikrein-related-peptidase-4 in Oral Cancer |pdf=|usr=}}{{25862839}} gab.com Text Clinical Significance of Kallikrein-related-peptidase-4 in Oral Cancer JO: Anticancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25862839 #FOAvip Kallikrein-related-peptidase-4 (KLK4), a serine protease originally discovered in developing tooth with broad target sequence specificity, serves vital functions in dental enamel formation. KLK4 is involved in degradation of extracellular matrix proteins and it is thought that this proteolytic activity could also promote tumor invasion and metastasis. Recent studies have associated KLK4 expression with tumor progression and clinical outcome, particularly in prostate and ovarian cancers. Very little is known in regard with KLK4 involvement in oral squamous cell carcinomas (OSCCs). Our objective was to investigate KLK4 expression in OSCC pathogenesis and disease progression. KLK4 expression was evaluated by immunohistochemistry, Western blots and zymograms in OSCC lines. Invasion assays using high versus low/undetectable KLK4-expressing OSCC cell lines were performed jointly with KLK4 siRNA inhibition. A large collection of OSCC specimens was evaluated for KLK4 expression and correlation with patients? characteristics and outcomes were determined. Our data indicates that KLK4 is differentially expressed in oral carcinomas. OSCC cell lines with high invasive and metastatic potential show the highest levels of KLK4 expression. KLK4 mRNA and protein expression is correlated with enzyme activity detected by zymograms. Inhibition of KLK4 expression results in diminished invasive potential in OSCC cell lines. Consistently, KLK4 expression is stronger in primary tumors that later either recurred or developed metastases suggesting that its preferential expression in OSCC might contribute to the individual tumor biology. Therefore, this study provides supportive evidence in favor of a prognostic value for KLK4 in OSCC and suggests that KLK4 could serve as a potential therapeutic target in oral cancer patients. Twit Text FOAVip Clinical Significance of Kallikrein-related-peptidase-4 in Oral Cancer ????Anticancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25862839 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25862839 #FOAvip English Wikipedia <ref>{{Cite pmid|25862839}}</ref> Clinical Significance of Kallikrein-related-peptidase-4 in Oral Cancer #MMPMID25862839 PAPAGERAKIS P; PANNONE G; ZHENG L; ATHANASSIOU-PAPAEFTHYMIOU M; YAMAKOSHI Y; McGUFF HS; SHKEIR O; GHIRTIS K; PAPAGERAKIS S Anticancer Res 2015[Apr]; 35 (4): 1861-6 PMID25862839show ga Kallikrein-related-peptidase-4 (KLK4), a serine protease originally discovered in developing tooth with broad target sequence specificity, serves vital functions in dental enamel formation. KLK4 is involved in degradation of extracellular matrix proteins and it is thought that this proteolytic activity could also promote tumor invasion and metastasis. Recent studies have associated KLK4 expression with tumor progression and clinical outcome, particularly in prostate and ovarian cancers. Very little is known in regard with KLK4 involvement in oral squamous cell carcinomas (OSCCs). Our objective was to investigate KLK4 expression in OSCC pathogenesis and disease progression. KLK4 expression was evaluated by immunohistochemistry, Western blots and zymograms in OSCC lines. Invasion assays using high versus low/undetectable KLK4-expressing OSCC cell lines were performed jointly with KLK4 siRNA inhibition. A large collection of OSCC specimens was evaluated for KLK4 expression and correlation with patients? characteristics and outcomes were determined. Our data indicates that KLK4 is differentially expressed in oral carcinomas. OSCC cell lines with high invasive and metastatic potential show the highest levels of KLK4 expression. KLK4 mRNA and protein expression is correlated with enzyme activity detected by zymograms. Inhibition of KLK4 expression results in diminished invasive potential in OSCC cell lines. Consistently, KLK4 expression is stronger in primary tumors that later either recurred or developed metastases suggesting that its preferential expression in OSCC might contribute to the individual tumor biology. Therefore, this study provides supportive evidence in favor of a prognostic value for KLK4 in OSCC and suggests that KLK4 could serve as a potential therapeutic target in oral cancer patients. äClinical Significance of Kallikrein-related-peptidase-4 in Oral Cancer(epmc).pdf DeepDyve Pubget Overpricing