Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1073/pnas.1501947112 http://scihub22266oqcxt.onion/10.1073/pnas.1501947112 C4577169!4577169!26316022     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (37): 11618-23 Nephropedia Template TP {{tp|p=26316022|t=2015. C5orf30 is a negative regulator of tissue damage in rheumatoid arthritis |pdf=|usr=}}{{26316022}} gab.com Text C5orf30 is a negative regulator of tissue damage in rheumatoid arthritis JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26316022 #FOAvip Recent studies have reported genetic association of chromosome 5 open reading frame 30 (C5orf30) with both rheumatoid arthritis (RA) susceptibility and the severity of radiological damage to joints. The gene is expressed in vertebrate genomes with a high degree of conservation, implying a central function in these organisms. Here, we report that C5orf30 encodes a 206-aa protein that is highly expressed in RA synovial fibroblasts (RASFs), a cell type implicated in causing joint damage. Importantly inhibition of C5orf30 increases the autoaggressive phenotype of RASFs in vitro and increases joint inflammation and damage in murine inflammatory arthritis. Our data reveals C5orf30 to be a negative regulator of tissue breakdown modulating the autoaggressive phenotype that is characteristic of RASFs. Twit Text FOAVip C5orf30 is a negative regulator of tissue damage in rheumatoid arthritis ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26316022 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26316022 #FOAvip English Wikipedia <ref>{{Cite pmid|26316022}}</ref> C5orf30 is a negative regulator of tissue damage in rheumatoid arthritis #MMPMID26316022 Muthana M; Hawtree S; Wilshaw A; Linehan E; Roberts H; Khetan S; Adeleke G; Wright F; Akil M; Fearon U; Veale D; Ciani B; Wilson AG Proc Natl Acad Sci U S A 2015[Sep]; 112 (37): 11618-23 PMID26316022show ga Recent studies have reported genetic association of chromosome 5 open reading frame 30 (C5orf30) with both rheumatoid arthritis (RA) susceptibility and the severity of radiological damage to joints. The gene is expressed in vertebrate genomes with a high degree of conservation, implying a central function in these organisms. Here, we report that C5orf30 encodes a 206-aa protein that is highly expressed in RA synovial fibroblasts (RASFs), a cell type implicated in causing joint damage. Importantly inhibition of C5orf30 increases the autoaggressive phenotype of RASFs in vitro and increases joint inflammation and damage in murine inflammatory arthritis. Our data reveals C5orf30 to be a negative regulator of tissue breakdown modulating the autoaggressive phenotype that is characteristic of RASFs. äC5orf30 is a negative regulator of tissue damage in rheumatoid arthrit(epmc).pdf DeepDyve Pubget Overpricing