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10.1073/pnas.1505512112 http://scihub22266oqcxt.onion/10.1073/pnas.1505512112 C4577147!4577147!26324895     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (37): E5169-78 Nephropedia Template TP {{tp|p=26324895|t=2015. Differential control of Yorkie activity by LKB1/AMPK and the Hippo/Warts cascade in the central nervous system |pdf=|usr=}}{{26324895}} gab.com Text Differential control of Yorkie activity by LKB1/AMPK and the Hippo/Warts cascade in the central nervous system JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26324895 #FOAvip The correct regulation of tissue growth in developing organisms is essential for functional organ formation. The evolutionarily conserved transcriptional coactivator Yorkie (Yki)/Yes-activated protein (YAP) responds to a variety of upstream inputs to promote tissue growth. Yki/YAP is known to regulate stem cell proliferation, thus affecting final organ size. The Hippo (Hpo)/Warts kinase cascade is a key inhibitor of Yki activity in many epithelial tissues. Here, we show that Yki is inhibited by the nutrient-sensing liver kinase B1 (LKB1)/AMP-activated protein kinase (AMPK) cascade independent of Hpo/Warts in a population of neural progenitors in the developing Drosophila larval brain. Our results suggest a tissue-specific nutrient-dependent mode of Yki activity regulation. Furthermore, a tissue-specific differential wiring of Hpo signaling could represent an adjustment to the proliferation requirements of different tissue types. Twit Text FOAVip Differential control of Yorkie activity by LKB1/AMPK and the Hippo/Warts cascade in the central nervous system ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26324895 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26324895 #FOAvip English Wikipedia <ref>{{Cite pmid|26324895}}</ref> Differential control of Yorkie activity by LKB1/AMPK and the Hippo/Warts cascade in the central nervous system #MMPMID26324895 Gailite I; Aerne BL; Tapon N Proc Natl Acad Sci U S A 2015[Sep]; 112 (37): E5169-78 PMID26324895show ga The correct regulation of tissue growth in developing organisms is essential for functional organ formation. The evolutionarily conserved transcriptional coactivator Yorkie (Yki)/Yes-activated protein (YAP) responds to a variety of upstream inputs to promote tissue growth. Yki/YAP is known to regulate stem cell proliferation, thus affecting final organ size. The Hippo (Hpo)/Warts kinase cascade is a key inhibitor of Yki activity in many epithelial tissues. Here, we show that Yki is inhibited by the nutrient-sensing liver kinase B1 (LKB1)/AMP-activated protein kinase (AMPK) cascade independent of Hpo/Warts in a population of neural progenitors in the developing Drosophila larval brain. Our results suggest a tissue-specific nutrient-dependent mode of Yki activity regulation. Furthermore, a tissue-specific differential wiring of Hpo signaling could represent an adjustment to the proliferation requirements of different tissue types. äDifferential control of Yorkie activity by LKB1/AMPK and the Hippo/War(epmc).pdf DeepDyve Pubget Overpricing