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10.1093/jrr/rrv031

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suck abstract from ncbi


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pmid26224888
      J+Radiat+Res 2015 ; 56 (5 ): 811-7
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  • Hypofractionated electron-beam radiation therapy for keloids: retrospective study of 568 cases with 834 lesions #MMPMID26224888
  • Shen J ; Lian X ; Sun Y ; Wang X ; Hu K ; Hou X ; Sun S ; Yan J ; Yu L ; Sun X ; Li W ; Wang X ; Guan Q ; Pang T ; Zhang F
  • J Radiat Res 2015[Sep]; 56 (5 ): 811-7 PMID26224888 show ga
  • We aimed to analyze the outcomes of hypofractionated high-energy electron beam radiotherapy for the treatment of keloids. From February 1998 to January 2012, 568 patients with a total of 834 keloids underwent radiotherapy: 826 lesions with postoperative radiotherapy, and 36 with skin-grafting. Lesion size was >5 cm in 335 keloids. An electron-beam of 6 or 7 MeV was used, with a total dose of 18 Gy (two fractions with a 1-week interval) covering the lesion with a 1-cm margin. The time between surgery and radiotherapy was 24-48 h. Skin-grafted patients underwent radiotherapy 10-15 days after the operation. The median follow-up was 40 months (range: 12-160 months). The local control rate was 88.25% (736/834). The relapse rate was 9.59% (80/834), and the time to relapse was 6-28 months (median: 12 months). Univariate analyses showed that gender, age, keloid size, keloid site, skin grafting, and operation-to-irradiation interval influenced the local control rate. Multivariate analysis showed that the relapse rate was correlated with gender (P = 0.048), age (P < 0.01), operation-to-irradiation interval (P < 0.01), keloid site (P < 0.01), surgical method (P = 0.04) and keloid size (P < 0.02). Adverse effects were observed in 9.83% (82/834). No radiation-induced cancers were observed. Hypofractionated high-energy electron beam radiotherapy for keloids yielded excellent outcomes, especially in cases without skin grafting. Early postoperative radiotherapy with limited hypofractionation could be a good choice for keloid treatment.
  • |Adolescent [MESH]
  • |Adult [MESH]
  • |Aged [MESH]
  • |Aged, 80 and over [MESH]
  • |Child [MESH]
  • |Child, Preschool [MESH]
  • |Dose Fractionation, Radiation [MESH]
  • |Electrons [MESH]
  • |Female [MESH]
  • |Follow-Up Studies [MESH]
  • |Humans [MESH]
  • |Keloid/pathology/*radiotherapy/*surgery [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Multivariate Analysis [MESH]
  • |Postoperative Period [MESH]
  • |Radiotherapy/*methods [MESH]
  • |Recurrence [MESH]
  • |Retrospective Studies [MESH]
  • |Treatment Outcome [MESH]


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