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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Radiat+Res
2015 ; 56
(5
): 811-7
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gab.com Text
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Hypofractionated electron-beam radiation therapy for keloids: retrospective study
of 568 cases with 834 lesions
#MMPMID26224888
Shen J
; Lian X
; Sun Y
; Wang X
; Hu K
; Hou X
; Sun S
; Yan J
; Yu L
; Sun X
; Li W
; Wang X
; Guan Q
; Pang T
; Zhang F
J Radiat Res
2015[Sep]; 56
(5
): 811-7
PMID26224888
show ga
We aimed to analyze the outcomes of hypofractionated high-energy electron beam
radiotherapy for the treatment of keloids. From February 1998 to January 2012,
568 patients with a total of 834 keloids underwent radiotherapy: 826 lesions with
postoperative radiotherapy, and 36 with skin-grafting. Lesion size was >5 cm in
335 keloids. An electron-beam of 6 or 7 MeV was used, with a total dose of 18 Gy
(two fractions with a 1-week interval) covering the lesion with a 1-cm margin.
The time between surgery and radiotherapy was 24-48 h. Skin-grafted patients
underwent radiotherapy 10-15 days after the operation. The median follow-up was
40 months (range: 12-160 months). The local control rate was 88.25% (736/834).
The relapse rate was 9.59% (80/834), and the time to relapse was 6-28 months
(median: 12 months). Univariate analyses showed that gender, age, keloid size,
keloid site, skin grafting, and operation-to-irradiation interval influenced the
local control rate. Multivariate analysis showed that the relapse rate was
correlated with gender (P = 0.048), age (P < 0.01), operation-to-irradiation
interval (P < 0.01), keloid site (P < 0.01), surgical method (P = 0.04) and
keloid size (P < 0.02). Adverse effects were observed in 9.83% (82/834). No
radiation-induced cancers were observed. Hypofractionated high-energy electron
beam radiotherapy for keloids yielded excellent outcomes, especially in cases
without skin grafting. Early postoperative radiotherapy with limited
hypofractionation could be a good choice for keloid treatment.