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10.5483/BMBRep.2015.48.8.107 http://scihub22266oqcxt.onion/10.5483/BMBRep.2015.48.8.107 C4576950!4576950!26058398     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMB+Rep 2015 ; 48 (8): 431-7 Nephropedia Template TP {{tp|p=26058398|t=2015. Phosphorylation-dependent regulation of Notch1 signaling: the fulcrum of Notch1 signaling |pdf=|usr=}}{{26058398}} gab.com Text Phosphorylation-dependent regulation of Notch1 signaling: the fulcrum of Notch1 signaling JO: BMB Rep http://www.kidney.de/pget.php?&tw=1&pmid=26058398 #FOAvip Notch signaling plays a pivotal role in cell fate determination, cellular development, cellular self-renewal, tumor progression, and has been linked to developmental disorders and carcinogenesis. Notch1 is activated through interactions with the ligands of neighboring cells, and acts as a transcriptional activator in the nucleus. The Notch1 intracellular domain (Notch1-IC) regulates the expression of target genes related to tumor development and progression. The Notch1 protein undergoes modification after translation by posttranslational modification enzymes. Phosphorylation modification is critical for enzymatic activation, complex formation, degradation, and subcellular localization. According to the nuclear cycle, Notch1-IC is degraded by E3 ligase, FBW7 in the nucleus via phosphorylation-dependent degradation. Here, we summarize the Notch signaling pathway, and resolve to understand the role of phosphorylation in the regulation of Notch signaling as well as to understand its relation to cancer. [BMB Reports 2015; 48(8): 431-437] Twit Text FOAVip Phosphorylation-dependent regulation of Notch1 signaling: the fulcrum of Notch1 signaling ????BMB Rep http://www.kidney.de/pget.php?&tw=1&pmid=26058398 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26058398 #FOAvip English Wikipedia <ref>{{Cite pmid|26058398}}</ref> Phosphorylation-dependent regulation of Notch1 signaling: the fulcrum of Notch1 signaling #MMPMID26058398 Lee HJ; Kim MY; Park HS BMB Rep 2015[Aug]; 48 (8): 431-7 PMID26058398show ga Notch signaling plays a pivotal role in cell fate determination, cellular development, cellular self-renewal, tumor progression, and has been linked to developmental disorders and carcinogenesis. Notch1 is activated through interactions with the ligands of neighboring cells, and acts as a transcriptional activator in the nucleus. The Notch1 intracellular domain (Notch1-IC) regulates the expression of target genes related to tumor development and progression. The Notch1 protein undergoes modification after translation by posttranslational modification enzymes. Phosphorylation modification is critical for enzymatic activation, complex formation, degradation, and subcellular localization. According to the nuclear cycle, Notch1-IC is degraded by E3 ligase, FBW7 in the nucleus via phosphorylation-dependent degradation. Here, we summarize the Notch signaling pathway, and resolve to understand the role of phosphorylation in the regulation of Notch signaling as well as to understand its relation to cancer. [BMB Reports 2015; 48(8): 431-437] äPhosphorylation-dependent regulation of Notch1 signaling: the fulcrum (epmc).pdf DeepDyve Pubget Overpricing