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Two low-dose bowel-cleansing regimens: efficacy and safety of senna and sodium
phosphorus solution for colonoscopy
#MMPMID26396504
Poyrazoglu OK
; Yalniz M
Patient Prefer Adherence
2015[]; 9
(?): 1325-31
PMID26396504
show ga
BACKGROUND: The aim of the present study was to compare the efficacy, adequacy,
side effects, and patient compliance of sodium phosphorus (NaP) and senna
solutions when preparing the colon before colonoscopy. METHODS: A total of 137
consecutive patients who were considered for colonoscopy evaluation had randomly
received one of two premeditated regimens: 90 mL of oral NaP (NaP group) or 500
mL of 1,000 mg of sennosides A and B calcium +66.6 g of sorbitol (senna group).
Patients' compliance with the bowel-cleansing method was determined using a
questionnaire prior to the colonoscopic examination. On the other hand, the
adequacy of the bowel-cleansing method was evaluated by the colonoscopist who was
blind to the bowel-cleansing regimen used prior to the examination of the colon
from the rectum to the cecum. RESULTS: Nausea and vomiting complaints were seen
more frequently in the NaP group than in the senna group (47 vs 28 and 31 vs 10;
P<0.05 and P<0.01, respectively). The response to the question of whether the
patients would like to use the same regimen again or not was similar in both
groups. The acceptable bowel-cleansing rate was also comparable across both
groups. Nevertheless, the number of patients that experienced excellent bowel
cleansing in terms of general appraisal of the colonoscopic evaluation was
significantly greater in the NaP group than in the senna group (46 vs 25;
P<0.001). CONCLUSION: Although bowel cleansing was better in the NaP group, both
cleansing regimens were comparable regarding the admissibility of the
preparations for the procedure. The senna regimen is, however, superior to the
NaP regimen in terms of application compliance and its side effects, and it may
be an effective alternative for cleansing the bowel prior to colonoscopic
examination.