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2015 ; 8
(ä): 2545-53
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Different setup errors assessed by weekly cone-beam computed tomography on
different registration in nasopharyngeal carcinoma treated with
intensity-modulated radiation therapy
#MMPMID26396530
Su J
; Chen W
; Yang H
; Hong J
; Zhang Z
; Yang G
; Li L
; Wei R
Onco Targets Ther
2015[]; 8
(ä): 2545-53
PMID26396530
show ga
The study aimed to investigate the difference of setup errors on different
registration in the treatment of nasopharyngeal carcinoma based on weekly
cone-beam computed tomography (CBCT). Thirty nasopharyngeal cancer patients
scheduled to undergo intensity-modulated radiotherapy (IMRT) were prospectively
enrolled in the study. Each patient had a weekly CBCT before radiation therapy.
In the entire study, 201 CBCT scans were obtained. The scans were registered to
the planning CT to determine the difference of setup errors on different
registration sites. Different registration sites were represented by bony
landmarks. Nasal septum and pterygoid process represent head, cervical vertebrae
1-3 represent upper neck, and cervical vertebrae 4-6 represent lower neck.
Patient positioning errors were recorded in the right-left (RL),
superior-inferior (SI), and anterior-posterior (AP) directions over the course of
radiotherapy. Planning target volume margins were calculated from the systematic
and random errors. In this study, we can make a conclusion that there are setup
errors in RL, SI, and AP directions of nasopharyngeal carcinoma patients
undergoing IMRT. In addition, the head and neck setup error has the difference,
with statistical significance, while patient setup error of neck is greater than
that of head during the course of radiotherapy. In our institution, we recommend
a planning target volume margin of 3.0 mm in RL direction, 1.3 mm in SI
direction, and 2.6 mm in AP direction for nasopharyngeal cancer patients
undergoing IMRT with weekly CBCT scans.