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10.1083/jcb.201502040 http://scihub22266oqcxt.onion/10.1083/jcb.201502040 C4576860!4576860 !26370503     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26370503 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26370503 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Biol 2015 ; 210 (6 ): 1013-31 Nephropedia Template TP {{tp|p=26370503 |t=2015. ?5?1 integrin recycling promotes Arp2/3-independent cancer cell invasion via the formin FHOD3 |pdf=|usr=}}{{26370503 }} gab.com Text 5 1 integrin recycling promotes Arp2/3-independent cancer cell invasion via the formin FHOD3 JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26370503 #FOAvip Invasive migration in 3D extracellular matrix (ECM) is crucial to cancer metastasis, yet little is known of the molecular mechanisms that drive reorganization of the cytoskeleton as cancer cells disseminate in vivo. 2D Rac-driven lamellipodial migration is well understood, but how these features apply to 3D migration is not clear. We find that lamellipodia-like protrusions and retrograde actin flow are indeed observed in cells moving in 3D ECM. However, Rab-coupling protein (RCP)-driven endocytic recycling of ?5?1 integrin enhances invasive migration of cancer cells into fibronectin-rich 3D ECM, driven by RhoA and filopodial spike-based protrusions, not lamellipodia. Furthermore, we show that actin spike protrusions are Arp2/3-independent. Dynamic actin spike assembly in cells invading in vitro and in vivo is regulated by Formin homology-2 domain containing 3 (FHOD3), which is activated by RhoA/ROCK, establishing a novel mechanism through which the RCP-?5?1 pathway reprograms the actin cytoskeleton to promote invasive migration and local invasion in vivo. Twit Text FOAVip 5 1 integrin recycling promotes Arp2/3-independent cancer cell invasion via the formin FHOD3 ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26370503 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26370503 #FOAvip English Wikipedia <ref>{{Cite pmid|26370503 }}</ref> ?5?1 integrin recycling promotes Arp2/3-independent cancer cell invasion via the formin FHOD3 #MMPMID26370503 Paul NR ; Allen JL ; Chapman A ; Morlan-Mairal M ; Zindy E ; Jacquemet G ; Fernandez del Ama L ; Ferizovic N ; Green DM ; Howe JD ; Ehler E ; Hurlstone A ; Caswell PT J Cell Biol 2015[Sep]; 210 (6 ): 1013-31 PMID26370503 show ga Invasive migration in 3D extracellular matrix (ECM) is crucial to cancer metastasis, yet little is known of the molecular mechanisms that drive reorganization of the cytoskeleton as cancer cells disseminate in vivo. 2D Rac-driven lamellipodial migration is well understood, but how these features apply to 3D migration is not clear. We find that lamellipodia-like protrusions and retrograde actin flow are indeed observed in cells moving in 3D ECM. However, Rab-coupling protein (RCP)-driven endocytic recycling of ?5?1 integrin enhances invasive migration of cancer cells into fibronectin-rich 3D ECM, driven by RhoA and filopodial spike-based protrusions, not lamellipodia. Furthermore, we show that actin spike protrusions are Arp2/3-independent. Dynamic actin spike assembly in cells invading in vitro and in vivo is regulated by Formin homology-2 domain containing 3 (FHOD3), which is activated by RhoA/ROCK, establishing a novel mechanism through which the RCP-?5?1 pathway reprograms the actin cytoskeleton to promote invasive migration and local invasion in vivo. |*Cell Movement [MESH] |*Signal Transduction [MESH] |Actin-Related Protein 2/genetics/*metabolism [MESH] |Actin-Related Protein 3/genetics/*metabolism [MESH] |Actins/metabolism [MESH] |Adaptor Proteins, Signal Transducing/metabolism [MESH] |Animals [MESH] |Cell Line, Tumor [MESH] |Female [MESH] |Formins [MESH] |Humans [MESH] |Integrin alpha5beta1/genetics/*metabolism [MESH] |Membrane Proteins/metabolism [MESH] |Microfilament Proteins/genetics/*metabolism [MESH] |Neoplasm Invasiveness [MESH] |Ovarian Neoplasms/genetics/*metabolism/pathology [MESH] |Phosphorylation [MESH] |Protein Transport [MESH] |Pseudopodia/*metabolism/pathology [MESH] |RNA Interference [MESH] |Time Factors [MESH] |Transfection [MESH] |Zebrafish [MESH]?5?1 integrin recycling promotes Arp2/3-independent cancer cell invasi(epmc).pdf DeepDyve Pubget Overpricing