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10.1016/j.bpj.2015.05.040 http://scihub22266oqcxt.onion/10.1016/j.bpj.2015.05.040 C4576150!4576150!26210208     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biophys+J 2015 ; 109 (6): 1149-56 Nephropedia Template TP {{tp|p=26210208|t=2015. A Molecular Dynamics Study of Allosteric Transitions in Leishmania mexicana Pyruvate Kinase |pdf=|usr=}}{{26210208}} gab.com Text A Molecular Dynamics Study of Allosteric Transitions in Leishmania mexicana Pyruvate Kinase JO: Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=26210208 #FOAvip A comparative molecular dynamics analysis of the pyruvate kinase from Leishmania mexicana is presented in the absence and presence of the allosteric effector fructose 2,6-bisphosphate. Comparisons of the simulations of the large 240 kDa apo and holo tetramers show that binding of fructose 2,6-bisphosphate cools the enzyme and reduces dynamic movement, particularly of the B-domain. The reduced dynamic movement of the holo form traps the pyruvate kinase tetramer in its enzymatically active state with the B-domain acting as a lid to cover the active site. The simulations are also consistent with a transition of the mobile active-site ?6? helix, which would adopt a helical conformation in the active R-state and a less structured coil conformation in the inactive T-state. Analysis of the rigid body motions over the trajectory highlights the concerted anticorrelated rigid body rocking motion of the four protomers, which drives the T to R transition. The transitions predicted by these simulations are largely consistent with the Monod-Wyman-Changeux model for allosteric activation but also suggest that rigidification or cooling of the overall structure upon effector binding plays an additional role in enzyme activation. Twit Text FOAVip A Molecular Dynamics Study of Allosteric Transitions in Leishmania mexicana Pyruvate Kinase ????Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=26210208 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26210208 #FOAvip English Wikipedia <ref>{{Cite pmid|26210208}}</ref> A Molecular Dynamics Study of Allosteric Transitions in Leishmania mexicana Pyruvate Kinase #MMPMID26210208 Naithani A; Taylor P; Erman B; Walkinshaw M Biophys J 2015[Sep]; 109 (6): 1149-56 PMID26210208show ga A comparative molecular dynamics analysis of the pyruvate kinase from Leishmania mexicana is presented in the absence and presence of the allosteric effector fructose 2,6-bisphosphate. Comparisons of the simulations of the large 240 kDa apo and holo tetramers show that binding of fructose 2,6-bisphosphate cools the enzyme and reduces dynamic movement, particularly of the B-domain. The reduced dynamic movement of the holo form traps the pyruvate kinase tetramer in its enzymatically active state with the B-domain acting as a lid to cover the active site. The simulations are also consistent with a transition of the mobile active-site ?6? helix, which would adopt a helical conformation in the active R-state and a less structured coil conformation in the inactive T-state. Analysis of the rigid body motions over the trajectory highlights the concerted anticorrelated rigid body rocking motion of the four protomers, which drives the T to R transition. The transitions predicted by these simulations are largely consistent with the Monod-Wyman-Changeux model for allosteric activation but also suggest that rigidification or cooling of the overall structure upon effector binding plays an additional role in enzyme activation. äA Molecular Dynamics Study of Allosteric Transitions in Leishmania mex(epmc).pdf DeepDyve Pubget Overpricing