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10.1038/icb.2015.33 http://scihub22266oqcxt.onion/10.1038/icb.2015.33 C4575951!4575951!25776846     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunol+Cell+Biol 2015 ; 93 (8): 727-34 Nephropedia Template TP {{tp|p=25776846|t=2015. Human thymic epithelial primary cells produce exosomes carrying tissue-restricted antigens |pdf=|usr=}}{{25776846}} gab.com Text Human thymic epithelial primary cells produce exosomes carrying tissue-restricted antigens JO: Immunol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25776846 #FOAvip Exosomes are nano-sized vesicles released by cells into the extracellular space and have been shown to be present in thymic tissue both in mice and in humans. The source of thymic exosomes is however still an enigma and hence it is not known whether thymic epithelial cells (TECs) are able to produce exosomes. In this work, we have cultured human TECs and isolated exosomes. These exosomes carry tissue-restricted antigens (TRAs), for example, myelin basic protein and desmoglein 3. The presence of TRAs indicates a possible role for thymic epithelium-derived exosomes in the selection process of thymocytes. The key contribution of these exosomes could be to disseminate self-antigens from the thymic epithelia, thus making them more accessible to the pool of maturing thymocytes. This would increase the coverage of TRAs within the thymus, and facilitate the process of positive and negative selection. Twit Text FOAVip Human thymic epithelial primary cells produce exosomes carrying tissue-restricted antigens ????Immunol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25776846 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25776846 #FOAvip English Wikipedia <ref>{{Cite pmid|25776846}}</ref> Human thymic epithelial primary cells produce exosomes carrying tissue-restricted antigens #MMPMID25776846 Skogberg G; Lundberg V; Berglund M; Gudmundsdottir J; Telemo E; Lindgren S; Ekwall O Immunol Cell Biol 2015[Sep]; 93 (8): 727-34 PMID25776846show ga Exosomes are nano-sized vesicles released by cells into the extracellular space and have been shown to be present in thymic tissue both in mice and in humans. The source of thymic exosomes is however still an enigma and hence it is not known whether thymic epithelial cells (TECs) are able to produce exosomes. In this work, we have cultured human TECs and isolated exosomes. These exosomes carry tissue-restricted antigens (TRAs), for example, myelin basic protein and desmoglein 3. The presence of TRAs indicates a possible role for thymic epithelium-derived exosomes in the selection process of thymocytes. The key contribution of these exosomes could be to disseminate self-antigens from the thymic epithelia, thus making them more accessible to the pool of maturing thymocytes. This would increase the coverage of TRAs within the thymus, and facilitate the process of positive and negative selection. äHuman thymic epithelial primary cells produce exosomes carrying tissue(epmc).pdf DeepDyve Pubget Overpricing