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10.1016/j.molcel.2015.07.026 http://scihub22266oqcxt.onion/10.1016/j.molcel.2015.07.026 C4575912!4575912 !26344095     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26344095 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Cell 2015 ; 59 (6 ): 917-30 Nephropedia Template TP {{tp|p=26344095 |t=2015. SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression |pdf=|usr=}}{{26344095 }} gab.com Text SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=26344095 #FOAvip The ERG gene is fused to TMPRSS2 in approximately 50% of prostate cancers (PrCa), resulting in its overexpression. However, whether this is the sole mechanism underlying ERG elevation in PrCa is currently unclear. Here we report that ERG ubiquitination and degradation are governed by the Cullin 3-based ubiquitin ligase SPOP and that deficiency in this pathway leads to aberrant elevation of the ERG oncoprotein. Specifically, we find that truncated ERG (?ERG), encoded by the ERG fusion gene, is stabilized by evading SPOP-mediated destruction, whereas prostate cancer-associated SPOP mutants are also deficient in promoting ERG ubiquitination. Furthermore, we show that the SPOP/ERG interaction is modulated by CKI-mediated phosphorylation. Importantly, we demonstrate that DNA damage drugs, topoisomerase inhibitors, can trigger CKI activation to restore the SPOP/?ERG interaction and its consequent degradation. Therefore, SPOP functions as a tumor suppressor to negatively regulate the stability of the ERG oncoprotein in prostate cancer. Twit Text FOAVip SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=26344095 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26344095 #FOAvip English Wikipedia <ref>{{Cite pmid|26344095 }}</ref> SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression #MMPMID26344095 Gan W ; Dai X ; Lunardi A ; Li Z ; Inuzuka H ; Liu P ; Varmeh S ; Zhang J ; Cheng L ; Sun Y ; Asara JM ; Beck AH ; Huang J ; Pandolfi PP ; Wei W Mol Cell 2015[Sep]; 59 (6 ): 917-30 PMID26344095 show ga The ERG gene is fused to TMPRSS2 in approximately 50% of prostate cancers (PrCa), resulting in its overexpression. However, whether this is the sole mechanism underlying ERG elevation in PrCa is currently unclear. Here we report that ERG ubiquitination and degradation are governed by the Cullin 3-based ubiquitin ligase SPOP and that deficiency in this pathway leads to aberrant elevation of the ERG oncoprotein. Specifically, we find that truncated ERG (?ERG), encoded by the ERG fusion gene, is stabilized by evading SPOP-mediated destruction, whereas prostate cancer-associated SPOP mutants are also deficient in promoting ERG ubiquitination. Furthermore, we show that the SPOP/ERG interaction is modulated by CKI-mediated phosphorylation. Importantly, we demonstrate that DNA damage drugs, topoisomerase inhibitors, can trigger CKI activation to restore the SPOP/?ERG interaction and its consequent degradation. Therefore, SPOP functions as a tumor suppressor to negatively regulate the stability of the ERG oncoprotein in prostate cancer. |*Ubiquitination [MESH] |Amino Acid Sequence [MESH] |Antineoplastic Agents, Phytogenic/pharmacology [MESH] |Cell Line, Tumor [MESH] |Cell Movement [MESH] |Cullin Proteins/metabolism [MESH] |Disease Progression [MESH] |Etoposide/pharmacology [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Male [MESH] |Molecular Sequence Data [MESH] |Neoplasm Invasiveness [MESH] |Nuclear Proteins/*physiology [MESH] |Prostatic Neoplasms/*metabolism/pathology [MESH] |Protein Interaction Domains and Motifs [MESH] |Proteolysis [MESH] |Repressor Proteins/*physiology [MESH] |Trans-Activators/*metabolism [MESH] |Transcriptional Regulator ERG [MESH]SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to(epmc).pdf DeepDyve Pubget Overpricing