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10.1016/j.molcel.2015.07.030 http://scihub22266oqcxt.onion/10.1016/j.molcel.2015.07.030 C4575883!4575883 !26365379     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26365379 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Cell 2015 ; 59 (6 ): 998-1010 Nephropedia Template TP {{tp|p=26365379 |t=2015. The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability |pdf=|usr=}}{{26365379 }} gab.com Text The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=26365379 #FOAvip The ATR replication checkpoint ensures that stalled forks remain stable when replisome movement is impeded. Using an improved iPOND protocol combined with SILAC mass spectrometry, we characterized human replisome dynamics in response to fork stalling. Our data provide a quantitative picture of the replisome and replication stress response proteomes in 32 experimental conditions. Importantly, rather than stabilize the replisome, the checkpoint prevents two distinct types of fork collapse. Unsupervised hierarchical clustering of protein abundance on nascent DNA is sufficient to identify protein complexes and place newly identified replisome-associated proteins into functional pathways. As an example, we demonstrate that ZNF644 complexes with the G9a/GLP methyltransferase at replication forks and is needed to prevent replication-associated DNA damage. Our data reveal how the replication checkpoint preserves genome integrity, provide insights into the mechanism of action of ATR inhibitors, and will be a useful resource for replication, DNA repair, and chromatin investigators. Twit Text FOAVip The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=26365379 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26365379 #FOAvip English Wikipedia <ref>{{Cite pmid|26365379 }}</ref> The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability #MMPMID26365379 Dungrawala H ; Rose KL ; Bhat KP ; Mohni KN ; Glick GG ; Couch FB ; Cortez D Mol Cell 2015[Sep]; 59 (6 ): 998-1010 PMID26365379 show ga The ATR replication checkpoint ensures that stalled forks remain stable when replisome movement is impeded. Using an improved iPOND protocol combined with SILAC mass spectrometry, we characterized human replisome dynamics in response to fork stalling. Our data provide a quantitative picture of the replisome and replication stress response proteomes in 32 experimental conditions. Importantly, rather than stabilize the replisome, the checkpoint prevents two distinct types of fork collapse. Unsupervised hierarchical clustering of protein abundance on nascent DNA is sufficient to identify protein complexes and place newly identified replisome-associated proteins into functional pathways. As an example, we demonstrate that ZNF644 complexes with the G9a/GLP methyltransferase at replication forks and is needed to prevent replication-associated DNA damage. Our data reveal how the replication checkpoint preserves genome integrity, provide insights into the mechanism of action of ATR inhibitors, and will be a useful resource for replication, DNA repair, and chromatin investigators. |*DNA Replication [MESH] |*S Phase Cell Cycle Checkpoints [MESH] |Ataxia Telangiectasia Mutated Proteins/metabolism [MESH] |Cell Line, Tumor [MESH] |DNA Damage [MESH] |DNA Helicases/metabolism [MESH] |DNA Repair Enzymes/metabolism [MESH] |DNA-Directed DNA Polymerase/metabolism [MESH] |Deoxyribonucleases/metabolism [MESH] |Enzyme Stability [MESH] |HEK293 Cells [MESH] |Humans [MESH]The Replication Checkpoint Prevents Two Types of Fork Collapse without(epmc).pdf DeepDyve Pubget Overpricing