Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/ng.3214 http://scihub22266oqcxt.onion/10.1038/ng.3214 C4575589!4575589!25665006     free     free     free       Nat+Genet 2015 ; 47 (3): 209-16 Nephropedia Template TP {{tp|p=25665006|t=2015. A Big Bang model of human colorectal tumor growth |pdf=|usr=}}{{25665006}} gab.com Text A Big Bang model of human colorectal tumor growth JO: Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=25665006 #FOAvip What happens in the early, still undetectable human malignancy is unknown because direct observations are impractical. Here we present and validate a ?Big Bang? model, whereby tumors grow predominantly as a single expansion producing numerous intermixed sub-clones that are not subject to stringent selection, and where both public (clonal) and most detectable private (subclonal) alterations arise early during growth. Genomic profiling of 349 individual glands from 15 colorectal tumors revealed the absence of selective sweeps, uniformly high intra-tumor heterogeneity (ITH), and sub-clone mixing in distant regions, as postulated by our model. We also verified the prediction that most detectable ITH originates from early private alterations, and not from later clonal expansions, thus exposing the profile of the primordial tumor. Moreover, some tumors appear born-to-be-bad, with sub-clone mixing indicative of early malignant potential. This new model provides a quantitative framework to interpret tumor growth dynamics and the origins of ITH with significant clinical implications. Twit Text FOAVip A Big Bang model of human colorectal tumor growth ????Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=25665006 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25665006 #FOAvip English Wikipedia <ref>{{Cite pmid|25665006}}</ref> A Big Bang model of human colorectal tumor growth #MMPMID25665006 Sottoriva A; Kang H; Ma Z; Graham TA; Salomon MP; Zhao J; Marjoram P; Siegmund K; Press MF; Shibata D; Curtis C Nat Genet 2015[Mar]; 47 (3): 209-16 PMID25665006show ga What happens in the early, still undetectable human malignancy is unknown because direct observations are impractical. Here we present and validate a ?Big Bang? model, whereby tumors grow predominantly as a single expansion producing numerous intermixed sub-clones that are not subject to stringent selection, and where both public (clonal) and most detectable private (subclonal) alterations arise early during growth. Genomic profiling of 349 individual glands from 15 colorectal tumors revealed the absence of selective sweeps, uniformly high intra-tumor heterogeneity (ITH), and sub-clone mixing in distant regions, as postulated by our model. We also verified the prediction that most detectable ITH originates from early private alterations, and not from later clonal expansions, thus exposing the profile of the primordial tumor. Moreover, some tumors appear born-to-be-bad, with sub-clone mixing indicative of early malignant potential. This new model provides a quantitative framework to interpret tumor growth dynamics and the origins of ITH with significant clinical implications. äA Big Bang model of human colorectal tumor growth (epmc).pdf DeepDyve Pubget Overpricing