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10.1113/JP270953 http://scihub22266oqcxt.onion/10.1113/JP270953 C4575567!4575567!26173176     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26173176&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Physiol 2015 ; 593 (Pt 17): 3773-88 Nephropedia Template TP {{tp|p=26173176|t=2015. Cardioprotection in ischaemia?reperfusion injury: novel mechanisms and clinical translation |pdf=|usr=}}{{26173176}} gab.com Text Cardioprotection in ischaemia reperfusion injury: novel mechanisms and clinical translation JO: J Physiol http://www.kidney.de/pget.php?&tw=1&pmid=26173176 #FOAvip In recent decades, robust successes have been achieved in conquering the acutely lethal manifestations of heart disease. Nevertheless, the prevalence of heart disease, especially heart failure, continues to rise. Among the precipitating aetiologies, ischaemic disease is a leading cause of heart failure. In the context of ischaemia, the myocardium is deprived of oxygen and nutrients, which elicits a cascade of events that provokes cell death. This ischaemic insult is typically coupled with reperfusion, either spontaneous or therapeutically imposed, wherein blood supply is restored to the previously ischaemic tissue. While this intervention limits ischaemic injury, it triggers a new cascade of events that is also harmful, viz. reperfusion injury. In recent years, novel insights have emerged regarding mechanisms of ischaemia?reperfusion injury, and some hold promise as targets of therapeutic relevance. Here, we review a select number of these pathways, focusing on recent discoveries and highlighting prospects for therapeutic manipulation for clinical benefit. Twit Text FOAVip Cardioprotection in ischaemia reperfusion injury: novel mechanisms and clinical translation ????J Physiol http://www.kidney.de/pget.php?&tw=1&pmid=26173176 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26173176 #FOAvip English Wikipedia <ref>{{Cite pmid|26173176}}</ref> Cardioprotection in ischaemia?reperfusion injury: novel mechanisms and clinical translation #MMPMID26173176 Altamirano F; Wang ZV; Hill JA J Physiol 2015[Sep]; 593 (Pt 17): 3773-88 PMID26173176show ga In recent decades, robust successes have been achieved in conquering the acutely lethal manifestations of heart disease. Nevertheless, the prevalence of heart disease, especially heart failure, continues to rise. Among the precipitating aetiologies, ischaemic disease is a leading cause of heart failure. In the context of ischaemia, the myocardium is deprived of oxygen and nutrients, which elicits a cascade of events that provokes cell death. This ischaemic insult is typically coupled with reperfusion, either spontaneous or therapeutically imposed, wherein blood supply is restored to the previously ischaemic tissue. While this intervention limits ischaemic injury, it triggers a new cascade of events that is also harmful, viz. reperfusion injury. In recent years, novel insights have emerged regarding mechanisms of ischaemia?reperfusion injury, and some hold promise as targets of therapeutic relevance. Here, we review a select number of these pathways, focusing on recent discoveries and highlighting prospects for therapeutic manipulation for clinical benefit. äCardioprotection in ischaemia?reperfusion injury: novel mechanisms and(epmc).pdf DeepDyve Pubget Overpricing