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10.1089/jop.2015.0017 http://scihub22266oqcxt.onion/10.1089/jop.2015.0017 C4575514!4575514!26352162     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Ocul+Pharmacol+Ther 2015 ; 31 (7): 413-8 Nephropedia Template TP {{tp|p=26352162|t=2015. TSP-1 Deficiency Alters Ocular Microbiota: Implications for Sjögren s Syndrome Pathogenesis |pdf=|usr=}}{{26352162}} gab.com Text TSP-1 Deficiency Alters Ocular Microbiota: Implications for Sjögren s Syndrome Pathogenesis JO: J Ocul Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=26352162 #FOAvip Purpose: The potential role of commensals as triggering factors that promote inflammation in dry eye disease has not been explored. The objective of this study was to evaluate whether ocular microbiota changes with the onset of dry eye disease in thrombospondin-1-deficient (TSP-1?/?) mice, a strain that develops Sjögren's syndrome-like disease.Methods: Conjunctival swabs were collected from TSP-1?/? and C57BL/6 mice and analyzed for bacterial presence. Opsonophagocytosis of the bacterial conjunctival isolates derived from the aged TSP-1?/? mice by neutrophils derived from either TSP-1?/? or C57BL/6 bone marrow was evaluated. The bactericidal activities of TSP-1-derived peptide were examined.Results: We found that in TSP-1?/? mice, the conjunctival colonization with Staphylococcus aureus and coagulase negative staphylococci sp(CNS) species was significantly increased with aging and preceded that of the wild-type C57BL/6 control mice. This correlated with increased neutrophil infiltration into the conjunctiva of the TSP-1?/? mice, suggesting that TSP-1 plays a significant role in regulating immunity to commensals. Accordingly, the TSP-1?/? PMNs opsonophagocytozed the ocular commensals less efficiently than the TSP-1-sufficient neutrophils. Furthermore, a TSP-1-derived peptide, 4N1K, exhibited significant antimicrobial activity when compared to a control peptide against commensal sp.Conclusion: These studies illustrate that alterations in the commensal frequency occur in the early stages of development of Sjögren's-like pathology and suggest that interventions that limit commensal outgrowth such as the use of TSP-1-derived peptides could be used for treatment during the early stages of the disease to reduce the commensal burden and ensuing inflammation. Twit Text FOAVip TSP-1 Deficiency Alters Ocular Microbiota: Implications for Sjögren s Syndrome Pathogenesis ????J Ocul Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=26352162 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26352162 #FOAvip English Wikipedia <ref>{{Cite pmid|26352162}}</ref> TSP-1 Deficiency Alters Ocular Microbiota: Implications for Sjögren s Syndrome Pathogenesis #MMPMID26352162 Terzulli M; Ruiz LC; Kugadas A; Masli S; Gadjeva M J Ocul Pharmacol Ther 2015[Sep]; 31 (7): 413-8 PMID26352162show ga Purpose: The potential role of commensals as triggering factors that promote inflammation in dry eye disease has not been explored. The objective of this study was to evaluate whether ocular microbiota changes with the onset of dry eye disease in thrombospondin-1-deficient (TSP-1?/?) mice, a strain that develops Sjögren's syndrome-like disease.Methods: Conjunctival swabs were collected from TSP-1?/? and C57BL/6 mice and analyzed for bacterial presence. Opsonophagocytosis of the bacterial conjunctival isolates derived from the aged TSP-1?/? mice by neutrophils derived from either TSP-1?/? or C57BL/6 bone marrow was evaluated. The bactericidal activities of TSP-1-derived peptide were examined.Results: We found that in TSP-1?/? mice, the conjunctival colonization with Staphylococcus aureus and coagulase negative staphylococci sp(CNS) species was significantly increased with aging and preceded that of the wild-type C57BL/6 control mice. This correlated with increased neutrophil infiltration into the conjunctiva of the TSP-1?/? mice, suggesting that TSP-1 plays a significant role in regulating immunity to commensals. Accordingly, the TSP-1?/? PMNs opsonophagocytozed the ocular commensals less efficiently than the TSP-1-sufficient neutrophils. Furthermore, a TSP-1-derived peptide, 4N1K, exhibited significant antimicrobial activity when compared to a control peptide against commensal sp.Conclusion: These studies illustrate that alterations in the commensal frequency occur in the early stages of development of Sjögren's-like pathology and suggest that interventions that limit commensal outgrowth such as the use of TSP-1-derived peptides could be used for treatment during the early stages of the disease to reduce the commensal burden and ensuing inflammation. äTSP-1 Deficiency Alters Ocular Microbiota: Implications for Sjögren s (epmc).pdf DeepDyve Pubget Overpricing