Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1097/FJC.0000000000000031 http://scihub22266oqcxt.onion/10.1097/FJC.0000000000000031 C4574629!4574629!24508946     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cardiovasc+Pharmacol 2014 ; 63 (2): 132-43 Nephropedia Template TP {{tp|p=24508946|t=2014. The Immunosuppressant FTY720 Prolongs Survival in a Mouse Model of Diet-induced Coronary Atherosclerosis and Myocardial Infarction |pdf=|usr=}}{{24508946}} gab.com Text The Immunosuppressant FTY720 Prolongs Survival in a Mouse Model of Diet-induced Coronary Atherosclerosis and Myocardial Infarction JO: J Cardiovasc Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=24508946 #FOAvip FTY720, an analogue of sphingosine-1-phosphate, is cardioprotective during acute injury. Whether long-term FTY720 affords cardioprotection is unknown. Here we report the effects of oral FTY720 on ischemia/reperfusion (I/R) injury and in HypoE mice deficient in SR-BI receptor expression (ApoeR61h/h/SRB1?/? mice), a model of diet-induced coronary atherosclerosis and heart failure. We added FTY720 (0.3mg/kg/day) to the drinking water of C57BL/6J mice. After ex vivo cardiac I/R injury these mice had significantly improved left ventricular (LV) developed pressure and reduced infarct size compared with controls. Subsequently, ApoeR61h/h/SRB1?/? mice fed a high fat diet (HFD) for 4 weeks were treated or not with oral FTY720 (0.05mg/kg/day). This sharply reduced mortality (P<0.02) and resulted in better LV function and less LV remodeling compared with controls without reducing hypercholesterolemia and atherosclerosis. Oral FTY720 reduced the number of blood lymphocytes and increased the percentage of CD4+Foxp3+ T cells (Tregs) in the circulation, spleen and lymph nodes. FTY720-treated mice exhibited increased TGF-? and reduced IFN-? expression in the heart. Also, CD4 expression was increased and strongly correlated with molecules involved in natural Treg activity, such as TGF-? and GITR. Our data suggest that long-term FTY720-treatment enhances LV function and increases longevity in mice with heart failure. These benefits resulted not from atheroprotection but from systemic immunosuppression and a moderate reduction of inflammation in the heart. Twit Text FOAVip The Immunosuppressant FTY720 Prolongs Survival in a Mouse Model of Diet-induced Coronary Atherosclerosis and Myocardial Infarction ????J Cardiovasc Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=24508946 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24508946 #FOAvip English Wikipedia <ref>{{Cite pmid|24508946}}</ref> The Immunosuppressant FTY720 Prolongs Survival in a Mouse Model of Diet-induced Coronary Atherosclerosis and Myocardial Infarction #MMPMID24508946 Wang G; Kim RY; Imhof I; Honbo N; Luk FS; Li K; Kumar N; Zhu Bq; Eberlé D; Ching D; Karliner JS; Raffai RL J Cardiovasc Pharmacol 2014[Feb]; 63 (2): 132-43 PMID24508946show ga FTY720, an analogue of sphingosine-1-phosphate, is cardioprotective during acute injury. Whether long-term FTY720 affords cardioprotection is unknown. Here we report the effects of oral FTY720 on ischemia/reperfusion (I/R) injury and in HypoE mice deficient in SR-BI receptor expression (ApoeR61h/h/SRB1?/? mice), a model of diet-induced coronary atherosclerosis and heart failure. We added FTY720 (0.3mg/kg/day) to the drinking water of C57BL/6J mice. After ex vivo cardiac I/R injury these mice had significantly improved left ventricular (LV) developed pressure and reduced infarct size compared with controls. Subsequently, ApoeR61h/h/SRB1?/? mice fed a high fat diet (HFD) for 4 weeks were treated or not with oral FTY720 (0.05mg/kg/day). This sharply reduced mortality (P<0.02) and resulted in better LV function and less LV remodeling compared with controls without reducing hypercholesterolemia and atherosclerosis. Oral FTY720 reduced the number of blood lymphocytes and increased the percentage of CD4+Foxp3+ T cells (Tregs) in the circulation, spleen and lymph nodes. FTY720-treated mice exhibited increased TGF-? and reduced IFN-? expression in the heart. Also, CD4 expression was increased and strongly correlated with molecules involved in natural Treg activity, such as TGF-? and GITR. Our data suggest that long-term FTY720-treatment enhances LV function and increases longevity in mice with heart failure. These benefits resulted not from atheroprotection but from systemic immunosuppression and a moderate reduction of inflammation in the heart. äThe Immunosuppressant FTY720 Prolongs Survival in a Mouse Model of Die(epmc).pdf DeepDyve Pubget Overpricing