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10.1186/s13059-015-0741-y

http://scihub22266oqcxt.onion/10.1186/s13059-015-0741-y
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suck abstract from ncbi

pmid26316348
      Genome+Biol 2015 ; 16 (1 ): 180
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  • Reconstructing A/B compartments as revealed by Hi-C using long-range correlations in epigenetic data #MMPMID26316348
  • Fortin JP ; Hansen KD
  • Genome Biol 2015[Aug]; 16 (1 ): 180 PMID26316348 show ga
  • Analysis of Hi-C data has shown that the genome can be divided into two compartments called A/B compartments. These compartments are cell-type specific and are associated with open and closed chromatin. We show that A/B compartments can reliably be estimated using epigenetic data from several different platforms: the Illumina 450 k DNA methylation microarray, DNase hypersensitivity sequencing, single-cell ATAC sequencing and single-cell whole-genome bisulfite sequencing. We do this by exploiting that the structure of long-range correlations differs between open and closed compartments. This work makes A/B compartment assignment readily available in a wide variety of cell types, including many human cancers.
  • |*DNA Methylation [MESH]
  • |*Epigenesis, Genetic [MESH]
  • |Base Composition [MESH]
  • |Chromatin/*chemistry [MESH]
  • |DNA/chemistry [MESH]
  • |Genomics [MESH]
  • |Humans [MESH]
  • |Male [MESH]
  • |Mutation Rate [MESH]
  • |Oligonucleotide Array Sequence Analysis [MESH]
  • |Prostatic Neoplasms/genetics [MESH]


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