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2015 ; 10
(ä): 187
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Dosimetric comparison of carbon ion radiotherapy and stereotactic body
radiotherapy with photon beams for the treatment of hepatocellular carcinoma
#MMPMID26377092
Abe T
; Saitoh J
; Kobayashi D
; Shibuya K
; Koyama Y
; Shimada H
; Shirai K
; Ohno T
; Nakano T
Radiat Oncol
2015[Sep]; 10
(ä): 187
PMID26377092
show ga
BACKGROUND: The purpose of this study was to compare carbon ion radiotherapy
(C-ion RT) and stereotactic radiotherapy (SBRT) with photon beams for the
treatment of hepatocellular carcinoma (HCC), specifically with regard to the dose
volume parameters for target coverage and normal tissue sparing. METHODS: Data of
10 patients who were treated using C-ion RT with a total dose of 60 Gy(RBE) in
four fractions were used. The virtual plan of SBRT was simulated on the treatment
planning computed tomography images of C-ion RT. Dose volume parameters such as
minimum dose covering 90% of the planning target volume (PTV D90), homogeneity
index (HI), conformity index (CI), mean liver dose (MLD), volume of the liver
receiving 5 to 60 Gy (V5-60), and max point dose (Dmax) of gastrointestinal (GI)
tract were calculated from both treatment plans. RESULTS: The PTV D90 was
59.6?±?0.2 Gy(RBE) in C-ion RT, as compared to 56.6?±?0.3 Gy in SBRT (p?0.05).
HI and CI were 1.19?±?0.03 and 0.79?±?0.06, respectively in C-ion RT, as compared
to 1.21?±?0.01 and 0.37?±?0.02, respectively in SBRT. Only CI showed a
significant difference between two modalities. Mean liver dose was 8.1?±?1.4
Gy(RBE) in C-ion RT, as compared to 16.1?±?2.5 Gy in SBRT (p?0.05). V5 to V50
of liver were higher in SBRT than C-ion RT and significant differences were
observed for V5, V10 and V20. Dmax of the GI tract was higher in SBRT than C-ion
RT, but did not show a significantly difference. CONCLUSIONS: C-ion RT provides
an advantage in both target conformity and normal liver sparing compared with
SBRT.