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2015 ; 12
(ä): 175
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Acute hemorrhagic leukoencephalitis (Weston-Hurst syndrome) in a patient with
relapse-remitting multiple sclerosis
#MMPMID26376717
Yildiz Ö
; Pul R
; Raab P
; Hartmann C
; Skripuletz T
; Stangel M
J Neuroinflammation
2015[Sep]; 12
(ä): 175
PMID26376717
show ga
Acute hemorrhagic leukoencephalitis is a fulminant demyelinating disease and
commonly considered as a rare and severe variant of acute disseminated
encephalomyelitis. Here, we report the clinical, magnetic resonance imaging, and
brain biopsy findings of a 35-year-old female with relapsing-remitting multiple
sclerosis, who developed acute hemorrhagic leukoencephalitis. Magnetic resonance
imaging revealed symmetrical hemorrhagic lesions in the basal ganglia including
the thalami. Disease progression was consistent with acute hemorrhagic
leukoencephalitis with rapid deterioration of consciousness and seizures. Besides
hemorrhage, infiltration of neutrophils was detected in brain biopsy.Acute
hemorrhagic leukoencephalitis, also known as Weston-Hurst syndrome, is an
excessive immunological response of unknown etiology. So far, an association with
multiple sclerosis has not been reported. The present case raises the question,
whether acute hemorrhagic leukoencephalitis is a specific hyperacute form of
acute disseminated encephalomyelitis, a severe and unspecific form of an immune
response in the central nervous system, or belongs to the spectrum of tumefactive
multiple sclerosis.