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10.1186/s13059-015-0748-4 http://scihub22266oqcxt.onion/10.1186/s13059-015-0748-4 C4574115!4574115 !26381124     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26381124 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genome+Biol 2015 ; 16 (1 ): 194 Nephropedia Template TP {{tp|p=26381124 |t=2015. The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans |pdf=|usr=}}{{26381124 }} gab.com Text The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans JO: Genome Biol http://www.kidney.de/pget.php?&tw=1&pmid=26381124 #FOAvip BACKGROUND: Cellular senescence is a stable arrest of proliferation and is considered a key component of processes associated with carcinogenesis and other ageing-related phenotypes. Here, we perform methylome analysis of actively dividing and deeply senescent normal human epithelial cells. RESULTS: We identify senescence-associated differentially methylated positions (senDMPs) from multiple experiments using cells from one donor. We find that human senDMP epigenetic signatures are positively and significantly correlated with both cancer and ageing-associated methylation dynamics. We also identify germline genetic variants, including those associated with the p16INK4A locus, which are associated with the presence of in vivo senDMP signatures. Importantly, we also demonstrate that a single senDMP signature can be effectively reversed in a newly-developed protocol of transient senescence reversal. CONCLUSIONS: The senDMP signature has significant potential for understanding some of the key (epi)genetic etiological factors that may lead to cancer and age-related diseases in humans. Twit Text FOAVip The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans ????Genome Biol http://www.kidney.de/pget.php?&tw=1&pmid=26381124 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26381124 #FOAvip English Wikipedia <ref>{{Cite pmid|26381124 }}</ref> The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans #MMPMID26381124 Lowe R ; Overhoff MG ; Ramagopalan SV ; Garbe JC ; Koh J ; Stampfer MR ; Beach DH ; Rakyan VK ; Bishop CL Genome Biol 2015[Sep]; 16 (1 ): 194 PMID26381124 show ga BACKGROUND: Cellular senescence is a stable arrest of proliferation and is considered a key component of processes associated with carcinogenesis and other ageing-related phenotypes. Here, we perform methylome analysis of actively dividing and deeply senescent normal human epithelial cells. RESULTS: We identify senescence-associated differentially methylated positions (senDMPs) from multiple experiments using cells from one donor. We find that human senDMP epigenetic signatures are positively and significantly correlated with both cancer and ageing-associated methylation dynamics. We also identify germline genetic variants, including those associated with the p16INK4A locus, which are associated with the presence of in vivo senDMP signatures. Importantly, we also demonstrate that a single senDMP signature can be effectively reversed in a newly-developed protocol of transient senescence reversal. CONCLUSIONS: The senDMP signature has significant potential for understanding some of the key (epi)genetic etiological factors that may lead to cancer and age-related diseases in humans. |*DNA Methylation [MESH] |Adult [MESH] |Aging/*genetics [MESH] |Cellular Senescence/*genetics [MESH] |Cyclin-Dependent Kinase Inhibitor p16/genetics [MESH] |Epigenesis, Genetic [MESH] |Female [MESH] |Genetic Variation [MESH] |Humans [MESH] |Neoplasms/*genetics [MESH] |Polymorphism, Single Nucleotide [MESH]The senescent methylome and its relationship with cancer, ageing and g(epmc).pdf DeepDyve Pubget Overpricing