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10.1186/s12943-015-0437-7 http://scihub22266oqcxt.onion/10.1186/s12943-015-0437-7 C4574028!4574028 !26376879     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26376879 &cmd=llinks): Failed to open stream: HTTP request failed! 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Aldolase B inhibits metastasis through Ten-Eleven Translocation 1 and serves as a prognostic biomarker in hepatocellular carcinoma |pdf=|usr=}}{{26376879 }} gab.com Text Aldolase B inhibits metastasis through Ten-Eleven Translocation 1 and serves as a prognostic biomarker in hepatocellular carcinoma JO: Mol Cancer http://www.kidney.de/pget.php?&tw=1&pmid=26376879 #FOAvip BACKGROUND: Downregulation of Aldolase B (ALDOB) has been reported in hepatocellular carcinoma. However, its clinical significance and its role in pathogenesis of HCC remain largely unknown. METHODS: We analyzed the expression of ALDOB and its clinical features in a large cohort of 313 HCC patients using tissue microarray and immunohistochemistry. Moreover, the function of stably overexpressed ALDOB in HCC cells was explored in vitro and in vivo. Gene expression microarray analysis was performed on ALDOB-overexpressing SMMC7721 cells to elucidate its mechanism of action. RESULTS: ALDOB downregulation in HCC was significantly correlated with aggressive characteristics including absence of encapsulation, increased tumor size (>5 cm) and early recurrence. ALDOB downregulation was indicative of a shorter recurrence-free survival (RFS) and overall survival (OS) for all HCC patients and early-stage HCC patients (BCLC 0-A and TNM I stage patients). Multiple analyses revealed that ALDOB downregulation was an independent risk factor of RFS and OS. Stable expression of ALDOB in HCC cell lines reduced cell migration in vitro and inhibited lung metastasis, intrahepatic metastasis, and reduced circulating tumor cells in vivo. Mechanistically, we found that cells stably expressing ALDOB show elevated Ten-Eleven Translocation 1 (TET1) expression. Moreover, ALDOB expressing cells have higher levels of methylglyoxal than do control cells, which can upregulate TET1 expression. CONCLUSION: The downregulation of ALDOB could indicate a poor prognosis for HCC patients, and therefore, ALDOB might be considered a prognostic biomarker for HCC, especially at the early stage. In addition, ALDOB inhibits the invasive features of cell lines partly through TET1 expression. Twit Text FOAVip Aldolase B inhibits metastasis through Ten-Eleven Translocation 1 and serves as a prognostic biomarker in hepatocellular carcinoma ????Mol Cancer http://www.kidney.de/pget.php?&tw=1&pmid=26376879 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26376879 #FOAvip English Wikipedia <ref>{{Cite pmid|26376879 }}</ref> Aldolase B inhibits metastasis through Ten-Eleven Translocation 1 and serves as a prognostic biomarker in hepatocellular carcinoma #MMPMID26376879 Tao QF ; Yuan SX ; Yang F ; Yang S ; Yang Y ; Yuan JH ; Wang ZG ; Xu QG ; Lin KY ; Cai J ; Yu J ; Huang WL ; Teng XL ; Zhou CC ; Wang F ; Sun SH ; Zhou WP Mol Cancer 2015[Sep]; 14 (ä): 170 PMID26376879 show ga BACKGROUND: Downregulation of Aldolase B (ALDOB) has been reported in hepatocellular carcinoma. However, its clinical significance and its role in pathogenesis of HCC remain largely unknown. METHODS: We analyzed the expression of ALDOB and its clinical features in a large cohort of 313 HCC patients using tissue microarray and immunohistochemistry. Moreover, the function of stably overexpressed ALDOB in HCC cells was explored in vitro and in vivo. Gene expression microarray analysis was performed on ALDOB-overexpressing SMMC7721 cells to elucidate its mechanism of action. RESULTS: ALDOB downregulation in HCC was significantly correlated with aggressive characteristics including absence of encapsulation, increased tumor size (>5 cm) and early recurrence. ALDOB downregulation was indicative of a shorter recurrence-free survival (RFS) and overall survival (OS) for all HCC patients and early-stage HCC patients (BCLC 0-A and TNM I stage patients). Multiple analyses revealed that ALDOB downregulation was an independent risk factor of RFS and OS. Stable expression of ALDOB in HCC cell lines reduced cell migration in vitro and inhibited lung metastasis, intrahepatic metastasis, and reduced circulating tumor cells in vivo. Mechanistically, we found that cells stably expressing ALDOB show elevated Ten-Eleven Translocation 1 (TET1) expression. Moreover, ALDOB expressing cells have higher levels of methylglyoxal than do control cells, which can upregulate TET1 expression. CONCLUSION: The downregulation of ALDOB could indicate a poor prognosis for HCC patients, and therefore, ALDOB might be considered a prognostic biomarker for HCC, especially at the early stage. In addition, ALDOB inhibits the invasive features of cell lines partly through TET1 expression. |Aged [MESH] |Animals [MESH] |Biomarkers, Tumor/*biosynthesis/genetics [MESH] |Carcinoma, Hepatocellular/*genetics/pathology [MESH] |Cell Movement/genetics [MESH] |Cell Proliferation/genetics [MESH] |DNA-Binding Proteins/*biosynthesis/genetics [MESH] |Disease-Free Survival [MESH] |Female [MESH] |Fructose-Bisphosphate Aldolase/*biosynthesis/genetics [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Liver Neoplasms/*genetics/pathology [MESH] |Male [MESH] |Mice [MESH] |Middle Aged [MESH] |Mixed Function Oxygenases [MESH] |Neoplasm Metastasis [MESH] |Prognosis [MESH] |Proto-Oncogene Proteins/*biosynthesis/genetics [MESH]Aldolase B inhibits metastasis through Ten-Eleven Translocation 1 and (epmc).pdf DeepDyve Pubget Overpricing