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10.1158/0008-5472.CAN-15-0037 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-15-0037 C4573896!4573896!26249176     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Res 2015 ; 75 (18): 3946-57 Nephropedia Template TP {{tp|p=26249176|t=2015. Heparanase enhances tumor growth and chemo-resistance by promoting autophagy |pdf=|usr=}}{{26249176}} gab.com Text Heparanase enhances tumor growth and chemo-resistance by promoting autophagy JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=26249176 #FOAvip Heparanase is the only enzyme in mammals capable of cleaving heparan sulfate, an activity implicated in tumor inflammation, angiogenesis and metastasis. Heparanase is secreted as a latent enzyme that is internalized and subjected to proteolytic processing and activation in lysosomes. Its role under normal conditions has yet to be understood. Here we provide evidence that heparanase resides within autophagosomes where studies in heparanase-deficient or transgenic mice established its contributions to autophagy. The pro-tumorigenic properties of heparanase were found to be mediated in part by its pro-autophagic function, as demonstrated in tumor xenograft models of human cancer and through use of inhibitors of the lysosome (chloroquine) and heparanase (PG545), both alone and in combination. Notably, heparanase-overexpressing cells were more resistant to stress and chemotherapy in a manner associated with increased autophagy, effects that were reversed by chloroquine treatment. Collectively, our results establish a role for heparanase in modulating autophagy in normal and malignant cells, thereby conferring growth advantages under stress as well as resistance to chemotherapy. Twit Text FOAVip Heparanase enhances tumor growth and chemo-resistance by promoting autophagy ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=26249176 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26249176 #FOAvip English Wikipedia <ref>{{Cite pmid|26249176}}</ref> Heparanase enhances tumor growth and chemo-resistance by promoting autophagy #MMPMID26249176 Shteingauz A; Boyango I; Naroditsky I; Hammond E; Gruber M; Doweck I; Ilan N; Vlodavsky I Cancer Res 2015[Sep]; 75 (18): 3946-57 PMID26249176show ga Heparanase is the only enzyme in mammals capable of cleaving heparan sulfate, an activity implicated in tumor inflammation, angiogenesis and metastasis. Heparanase is secreted as a latent enzyme that is internalized and subjected to proteolytic processing and activation in lysosomes. Its role under normal conditions has yet to be understood. Here we provide evidence that heparanase resides within autophagosomes where studies in heparanase-deficient or transgenic mice established its contributions to autophagy. The pro-tumorigenic properties of heparanase were found to be mediated in part by its pro-autophagic function, as demonstrated in tumor xenograft models of human cancer and through use of inhibitors of the lysosome (chloroquine) and heparanase (PG545), both alone and in combination. Notably, heparanase-overexpressing cells were more resistant to stress and chemotherapy in a manner associated with increased autophagy, effects that were reversed by chloroquine treatment. Collectively, our results establish a role for heparanase in modulating autophagy in normal and malignant cells, thereby conferring growth advantages under stress as well as resistance to chemotherapy. äHeparanase enhances tumor growth and chemo-resistance by promoting aut(epmc).pdf DeepDyve Pubget Overpricing