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10.1158/0008-5472.CAN-14-3363 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-14-3363 C4573836!4573836!26292362     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Res 2015 ; 75 (18): 3925-35 Nephropedia Template TP {{tp|p=26292362|t=2015. ?Np63? promotes breast cancer cell motility through the selective activation of components of the epithelial-to-mesenchymal transition program |pdf=|usr=}}{{26292362}} gab.com Text Np63 promotes breast cancer cell motility through the selective activation of components of the epithelial-to-mesenchymal transition program JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=26292362 #FOAvip Cell identity signals influence the invasive capability of tumor cells, as demonstrated by the selection for programs of epithelial-to-mesenchymal transition (EMT) during malignant progression. Breast cancer cells retain canonical epithelial traits and invade collectively as cohesive groups of cells, but the signaling pathways critical to their invasive capabilities are still incompletely understood. Here we report that the transcription factor ?Np63? drives the migration of basal-like breast cancer (BLBC) cells by inducing a hybrid mesenchymal/epithelial state. Through a combination of expression analysis and functional testing across multiple BLBC cell populations, we determined that ?Np63? induces migration by elevating the expression of the EMT program components Slug and Axl. Interestingly, ?Np63? also increased the expression of miR205, which can silence ZEB1/2 to prevent the loss of epithelial character caused by EMT induction. In clinical specimens, co-expression of various elements of the ?Np63? pathway confirmed its implication in motility signaling in BLBC. We observed that activation of the ?Np63? pathway occurred during the transition from noninvasive ductal carcinoma in situ to invasive breast cancer. Notably, in an orthotopic tumor model, Slug expression was sufficient to induce collective invasion of E-cadherin expressing BLBC cells. Together, our results illustrate how ?Np63? can drive breast cancer cell invasion by selectively engaging pro-migratory components of the EMT program while, in parallel, still promoting the retention of epithelial character. Twit Text FOAVip Np63 promotes breast cancer cell motility through the selective activation of components of the epithelial-to-mesenchymal transition program ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=26292362 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26292362 #FOAvip English Wikipedia <ref>{{Cite pmid|26292362}}</ref> ?Np63? promotes breast cancer cell motility through the selective activation of components of the epithelial-to-mesenchymal transition program #MMPMID26292362 Dang TT; Esparza MA; Maine EA; Westcott JM; Pearson GW Cancer Res 2015[Sep]; 75 (18): 3925-35 PMID26292362show ga Cell identity signals influence the invasive capability of tumor cells, as demonstrated by the selection for programs of epithelial-to-mesenchymal transition (EMT) during malignant progression. Breast cancer cells retain canonical epithelial traits and invade collectively as cohesive groups of cells, but the signaling pathways critical to their invasive capabilities are still incompletely understood. Here we report that the transcription factor ?Np63? drives the migration of basal-like breast cancer (BLBC) cells by inducing a hybrid mesenchymal/epithelial state. Through a combination of expression analysis and functional testing across multiple BLBC cell populations, we determined that ?Np63? induces migration by elevating the expression of the EMT program components Slug and Axl. Interestingly, ?Np63? also increased the expression of miR205, which can silence ZEB1/2 to prevent the loss of epithelial character caused by EMT induction. In clinical specimens, co-expression of various elements of the ?Np63? pathway confirmed its implication in motility signaling in BLBC. We observed that activation of the ?Np63? pathway occurred during the transition from noninvasive ductal carcinoma in situ to invasive breast cancer. Notably, in an orthotopic tumor model, Slug expression was sufficient to induce collective invasion of E-cadherin expressing BLBC cells. Together, our results illustrate how ?Np63? can drive breast cancer cell invasion by selectively engaging pro-migratory components of the EMT program while, in parallel, still promoting the retention of epithelial character. ä?Np63? promotes breast cancer cell motility through the selective acti(epmc).pdf DeepDyve Pubget Overpricing