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10.1002/ijc.29519 http://scihub22266oqcxt.onion/10.1002/ijc.29519 C4573780!4573780!25784597     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Cancer 2016 ; 138 (5): 1058-66 Nephropedia Template TP {{tp|p=25784597|t=2016. HIF-1 at the crossroads of hypoxia, inflammation, and cancer |pdf=|usr=}}{{25784597}} gab.com Text HIF-1 at the crossroads of hypoxia, inflammation, and cancer JO: Int J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=25784597 #FOAvip The complex cross-talk of intricate inter-cellular signaling networks between the tumor and stromal cells promotes cancer progression. Hypoxia is one of the most common conditions encountered within the tumor microenvironment that drives tumor progression. Most responses to hypoxia are elicited by a family of transcription factors called hypoxia-inducible factors (HIFs), which induce expression of a diverse set of genes that assist cells to adapt to hypoxic environments. Among the three HIF protein family members, the role of HIF-1 is well established in cancer progression. HIF-1 functions as a signaling hub to coordinate the activities of many transcription factors and signaling molecules that impact tumorigenesis. This mini review discusses the complex role of HIF-1 and its context-dependent partners under various cancer-promoting events including inflammation and generation of cancer stem cells (CSCs), which are implicated in tumor metastasis and relapse. In addition, the review highlights the importance of therapeutic targeting of HIF-1 for cancer prevention. Twit Text FOAVip HIF-1 at the crossroads of hypoxia, inflammation, and cancer ????Int J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=25784597 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25784597 #FOAvip English Wikipedia <ref>{{Cite pmid|25784597}}</ref> HIF-1 at the crossroads of hypoxia, inflammation, and cancer #MMPMID25784597 Balamurugan K Int J Cancer 2016[Mar]; 138 (5): 1058-66 PMID25784597show ga The complex cross-talk of intricate inter-cellular signaling networks between the tumor and stromal cells promotes cancer progression. Hypoxia is one of the most common conditions encountered within the tumor microenvironment that drives tumor progression. Most responses to hypoxia are elicited by a family of transcription factors called hypoxia-inducible factors (HIFs), which induce expression of a diverse set of genes that assist cells to adapt to hypoxic environments. Among the three HIF protein family members, the role of HIF-1 is well established in cancer progression. HIF-1 functions as a signaling hub to coordinate the activities of many transcription factors and signaling molecules that impact tumorigenesis. This mini review discusses the complex role of HIF-1 and its context-dependent partners under various cancer-promoting events including inflammation and generation of cancer stem cells (CSCs), which are implicated in tumor metastasis and relapse. In addition, the review highlights the importance of therapeutic targeting of HIF-1 for cancer prevention. äHIF-1 at the crossroads of hypoxia, inflammation, and cancer (epmc).pdf DeepDyve Pubget Overpricing