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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Biol+Direct 2015 ; 10 (ä): ä Nephropedia Template TP
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Why the Central Dogma: on the nature of the great biological exclusion principle #MMPMID26377089
Koonin EV
Biol Direct 2015[]; 10 (ä): ä PMID26377089show ga
Abstract: The Central Dogma of molecular biology posits that transfer of information from proteins back to nucleic acids does not occur in biological systems. I argue that the impossibility of reverse translation is indeed a major, physical exclusion principle that emerges due to the transition from the digital information carriers, nucleic acids, to analog information carriers, proteins, which involves irreversible suppression of the digital information. Reviewers: This article was reviewed by Itai Yanai, Martin Lercher and Frank Eisenhaber.