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2011 ; 31
(5
): 295-302
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Neuron-glia interactions: the roles of Schwann cells in neuromuscular synapse
formation and function
#MMPMID21517783
Sugiura Y
; Lin W
Biosci Rep
2011[Oct]; 31
(5
): 295-302
PMID21517783
show ga
The NMJ (neuromuscular junction) serves as the ultimate output of the motor
neurons. The NMJ is composed of a presynaptic nerve terminal, a postsynaptic
muscle and perisynaptic glial cells. Emerging evidence has also demonstrated an
existence of perisynaptic fibroblast-like cells at the NMJ. In this review, we
discuss the importance of Schwann cells, the glial component of the NMJ, in the
formation and function of the NMJ. During development, Schwann cells are closely
associated with presynaptic nerve terminals and are required for the maintenance
of the developing NMJ. After the establishment of the NMJ, Schwann cells actively
modulate synaptic activity. Schwann cells also play critical roles in
regeneration of the NMJ after nerve injury. Thus, Schwann cells are indispensable
for formation and function of the NMJ. Further examination of the interplay among
Schwann cells, the nerve and the muscle will provide insights into a better
understanding of mechanisms underlying neuromuscular synapse formation and
function.