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10.1371/journal.pone.0138159 http://scihub22266oqcxt.onion/10.1371/journal.pone.0138159 C4573328!4573328!26376075     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2015 ; 10 (9): ä Nephropedia Template TP {{tp|p=26376075|t=2015. Serum Gamma-Glutamyltransferase Levels Predict Clinical Outcomes in Hemodialysis Patients |pdf=|usr=}}{{26376075}} gab.com Text Serum Gamma-Glutamyltransferase Levels Predict Clinical Outcomes in Hemodialysis Patients JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26376075 #FOAvip Background: Gamma-glutamyltransferase (GGT) is a biomarker of liver injury. GGT has also been reported to be a marker of oxidative stress and a predictor of mortality in the general population. Hemodialysis (HD) patients suffer from oxidative stress. The aim of our study was to investigate the relationship between serum GGT levels and clinical outcomes in HD patients. Methods: A total of 1,634 HD patients were enrolled from the Clinical Research Center registry for end-stage renal disease, a prospective cohort in Korea. Patients were categorized into three groups by tertiles of serum GGT levels. The primary outcome was all-cause, cardiovascular, or infection-related mortality and hospitalization. Results: During the median follow-up period of 30 months, the highest tertile of serum GGT levels had a significantly higher risk for all-cause mortality (hazard ratio (HR) 2.39, 95% confidence interval (CI), 1.55?3.69, P<0.001), cardiovascular mortality (HR 2.14, 95% CI, 1.07?4.26, P = 0.031) and infection-related mortality (HR 3.07, 95% CI, 1.30?7.25, P = 0.011) using tertile 1 as the reference group after adjusting for clinical variables including liver diseases. The highest tertile also had a significantly higher risk for first hospitalization (HR 1.22, 95% CI, 1.00?1.48, P = 0.048) and cardiovascular hospitalization (HR 1.42, 95% CI, 1.06?1.92, P = 0.028). Conclusions: Our data demonstrate that high serum GGT levels were an independent risk factor for all-cause, cardiovascular, and infection-related mortality, as well as cardiovascular hospitalization in HD patients. These findings suggest that serum GGT levels might be a useful biomarker to predict clinical outcomes in HD patients. Twit Text FOAVip Serum Gamma-Glutamyltransferase Levels Predict Clinical Outcomes in Hemodialysis Patients ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26376075 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26376075 #FOAvip English Wikipedia <ref>{{Cite pmid|26376075}}</ref> Serum Gamma-Glutamyltransferase Levels Predict Clinical Outcomes in Hemodialysis Patients #MMPMID26376075 Park WY; Koh ES; Kim SH; Kim YO; Jin DC; Song HC; Choi EJ; Kim YL; Kim YS; Kang SW; Kim NH; Yang CW; Kim YK PLoS One 2015[]; 10 (9): ä PMID26376075show ga Background: Gamma-glutamyltransferase (GGT) is a biomarker of liver injury. GGT has also been reported to be a marker of oxidative stress and a predictor of mortality in the general population. Hemodialysis (HD) patients suffer from oxidative stress. The aim of our study was to investigate the relationship between serum GGT levels and clinical outcomes in HD patients. Methods: A total of 1,634 HD patients were enrolled from the Clinical Research Center registry for end-stage renal disease, a prospective cohort in Korea. Patients were categorized into three groups by tertiles of serum GGT levels. The primary outcome was all-cause, cardiovascular, or infection-related mortality and hospitalization. Results: During the median follow-up period of 30 months, the highest tertile of serum GGT levels had a significantly higher risk for all-cause mortality (hazard ratio (HR) 2.39, 95% confidence interval (CI), 1.55?3.69, P<0.001), cardiovascular mortality (HR 2.14, 95% CI, 1.07?4.26, P = 0.031) and infection-related mortality (HR 3.07, 95% CI, 1.30?7.25, P = 0.011) using tertile 1 as the reference group after adjusting for clinical variables including liver diseases. The highest tertile also had a significantly higher risk for first hospitalization (HR 1.22, 95% CI, 1.00?1.48, P = 0.048) and cardiovascular hospitalization (HR 1.42, 95% CI, 1.06?1.92, P = 0.028). Conclusions: Our data demonstrate that high serum GGT levels were an independent risk factor for all-cause, cardiovascular, and infection-related mortality, as well as cardiovascular hospitalization in HD patients. These findings suggest that serum GGT levels might be a useful biomarker to predict clinical outcomes in HD patients. äSerum Gamma-Glutamyltransferase Levels Predict Clinical Outcomes in He(epmc).pdf DeepDyve Pubget Overpricing