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10.1186/s12929-015-0183-6 http://scihub22266oqcxt.onion/10.1186/s12929-015-0183-6 C4573290!4573290!26381729     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biomed+Sci 2015 ; 22 (1): ä Nephropedia Template TP {{tp|p=26381729|t=2015. Undercarboxylated osteocalcin as a biomarker of subclinical atherosclerosis in non-dialysis patients with chronic kidney disease |pdf=|usr=}}{{26381729}} gab.com Text Undercarboxylated osteocalcin as a biomarker of subclinical atherosclerosis in non-dialysis patients with chronic kidney disease JO: J Biomed Sci http://www.kidney.de/pget.php?&tw=1&pmid=26381729 #FOAvip Background: Studies in recent years have shown that undercarboxylated osteocalcin (uOC) not only maintains bone mineralization, but is also involved in the regulation of atherosclerosis. However, a correlation between uOC and carotid atherosclerosis in non-dialysis patients with chronic kidney disease (CKD) has not been investigated.A total of 240 non-dialysis patients with CKD were included in the study. For these patients, the median estimated glomerular filtration rate (eGFR) was 20.05 (12.43?49.32) ml/min/1.73m2. Serum uOC levels were measured using enzyme-linked immunosorbent assay (ELISA). Carotid ultrasonography was performed to assess carotid atherosclerotic plaques and intima?media thickness (IMT) in an attempt to analyze the relationship between uOC level and carotid atherosclerosis. Results: The uOC levels of non-dialysis patients with CKD were significantly lower than those of healthy controls [28.16 (21.40?45.85) ng/mL vs. 36.42 (28.05?49.28) ng/mL, P?<?0.01]. The uOC levels gradually decreased as CKD progressed (P?<?0.01). The uOC levels were significantly lower in patients with carotid plaques than in patients without carotid plaques [25.98 (20.14?31.35) ng/mL vs. 31.02 (25.86?36.40) ng/mL, P?<?0.01]. uOC level showed significant negative correlation with IMT (r?=?-0.33, P?<?0.01). Logistic regression analysis revealed that after adjustment for various confounding factors, decreased uOC levels were shown to indicate increased possibility of carotid atherosclerotic plaque development in non-dialysis patients with CKD (on every 1 SD decrease in the uOC level, odds ratio 1.70, 95 % confidence interval 1.24?2.98, P?<?0.01). Multivariate stepwise regression analysis demonstrated that decreased uOC level (??=?-0.163, P?<?0.05) was an independent risk factor for increased carotid IMT in non-dialysis patients with CKD. Conclusion: Serum uOC levels in non-dialysis patients with CKD are significantly lower than those in healthy individuals, and uOC is closely associated with subclinical atherosclerosis in CKD patients. Twit Text FOAVip Undercarboxylated osteocalcin as a biomarker of subclinical atherosclerosis in non-dialysis patients with chronic kidney disease ????J Biomed Sci http://www.kidney.de/pget.php?&tw=1&pmid=26381729 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26381729 #FOAvip English Wikipedia <ref>{{Cite pmid|26381729}}</ref> Undercarboxylated osteocalcin as a biomarker of subclinical atherosclerosis in non-dialysis patients with chronic kidney disease #MMPMID26381729 Zhang M; Ni Z; Zhou W; Qian J J Biomed Sci 2015[]; 22 (1): ä PMID26381729show ga Background: Studies in recent years have shown that undercarboxylated osteocalcin (uOC) not only maintains bone mineralization, but is also involved in the regulation of atherosclerosis. However, a correlation between uOC and carotid atherosclerosis in non-dialysis patients with chronic kidney disease (CKD) has not been investigated.A total of 240 non-dialysis patients with CKD were included in the study. For these patients, the median estimated glomerular filtration rate (eGFR) was 20.05 (12.43?49.32) ml/min/1.73m2. Serum uOC levels were measured using enzyme-linked immunosorbent assay (ELISA). Carotid ultrasonography was performed to assess carotid atherosclerotic plaques and intima?media thickness (IMT) in an attempt to analyze the relationship between uOC level and carotid atherosclerosis. Results: The uOC levels of non-dialysis patients with CKD were significantly lower than those of healthy controls [28.16 (21.40?45.85) ng/mL vs. 36.42 (28.05?49.28) ng/mL, P? äUndercarboxylated osteocalcin as a biomarker of subclinical atheroscle(epmc).pdf DeepDyve Pubget Overpricing