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10.1186/s12929-015-0183-6 http://scihub22266oqcxt.onion/10.1186/s12929-015-0183-6 C4573290!4573290 !26381729     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26381729 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Biomed+Sci 2015 ; 22 (1 ): 75 Nephropedia Template TP {{tp|p=26381729 |t=2015. Undercarboxylated osteocalcin as a biomarker of subclinical atherosclerosis in non-dialysis patients with chronic kidney disease |pdf=|usr=}}{{26381729 }} gab.com Text Undercarboxylated osteocalcin as a biomarker of subclinical atherosclerosis in non-dialysis patients with chronic kidney disease JO: J Biomed Sci http://www.kidney.de/pget.php?&tw=1&pmid=26381729 #FOAvip BACKGROUND: Studies in recent years have shown that undercarboxylated osteocalcin (uOC) not only maintains bone mineralization, but is also involved in the regulation of atherosclerosis. However, a correlation between uOC and carotid atherosclerosis in non-dialysis patients with chronic kidney disease (CKD) has not been investigated. A total of 240 non-dialysis patients with CKD were included in the study. For these patients, the median estimated glomerular filtration rate (eGFR) was 20.05 (12.43-49.32) ml/min/1.73m(2). Serum uOC levels were measured using enzyme-linked immunosorbent assay (ELISA). Carotid ultrasonography was performed to assess carotid atherosclerotic plaques and intima-media thickness (IMT) in an attempt to analyze the relationship between uOC level and carotid atherosclerosis. RESULTS: The uOC levels of non-dialysis patients with CKD were significantly lower than those of healthy controls [28.16 (21.40-45.85) ng/mL vs. 36.42 (28.05-49.28) ng/mL, P?<?0.01]. The uOC levels gradually decreased as CKD progressed (P?<?0.01). The uOC levels were significantly lower in patients with carotid plaques than in patients without carotid plaques [25.98 (20.14-31.35) ng/mL vs. 31.02 (25.86-36.40) ng/mL, P?<?0.01]. uOC level showed significant negative correlation with IMT (r?=?-0.33, P?<?0.01). Logistic regression analysis revealed that after adjustment for various confounding factors, decreased uOC levels were shown to indicate increased possibility of carotid atherosclerotic plaque development in non-dialysis patients with CKD (on every 1 SD decrease in the uOC level, odds ratio 1.70, 95 % confidence interval 1.24-2.98, P?<?0.01). Multivariate stepwise regression analysis demonstrated that decreased uOC level (??=?-0.163, P?<?0.05) was an independent risk factor for increased carotid IMT in non-dialysis patients with CKD. CONCLUSION: Serum uOC levels in non-dialysis patients with CKD are significantly lower than those in healthy individuals, and uOC is closely associated with subclinical atherosclerosis in CKD patients. Twit Text FOAVip Undercarboxylated osteocalcin as a biomarker of subclinical atherosclerosis in non-dialysis patients with chronic kidney disease ????J Biomed Sci http://www.kidney.de/pget.php?&tw=1&pmid=26381729 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26381729 #FOAvip English Wikipedia <ref>{{Cite pmid|26381729 }}</ref> Undercarboxylated osteocalcin as a biomarker of subclinical atherosclerosis in non-dialysis patients with chronic kidney disease #MMPMID26381729 Zhang M ; Ni Z ; Zhou W ; Qian J J Biomed Sci 2015[Sep]; 22 (1 ): 75 PMID26381729 show ga BACKGROUND: Studies in recent years have shown that undercarboxylated osteocalcin (uOC) not only maintains bone mineralization, but is also involved in the regulation of atherosclerosis. However, a correlation between uOC and carotid atherosclerosis in non-dialysis patients with chronic kidney disease (CKD) has not been investigated. A total of 240 non-dialysis patients with CKD were included in the study. For these patients, the median estimated glomerular filtration rate (eGFR) was 20.05 (12.43-49.32) ml/min/1.73m(2). Serum uOC levels were measured using enzyme-linked immunosorbent assay (ELISA). Carotid ultrasonography was performed to assess carotid atherosclerotic plaques and intima-media thickness (IMT) in an attempt to analyze the relationship between uOC level and carotid atherosclerosis. RESULTS: The uOC levels of non-dialysis patients with CKD were significantly lower than those of healthy controls [28.16 (21.40-45.85) ng/mL vs. 36.42 (28.05-49.28) ng/mL, P? |Aged [MESH] |Atherosclerosis/*blood/diagnostic imaging/etiology [MESH] |Biomarkers/blood [MESH] |Carotid Intima-Media Thickness [MESH] |Female [MESH] |Humans [MESH] |Male [MESH] |Middle Aged [MESH] |Osteocalcin/*blood [MESH]Undercarboxylated osteocalcin as a biomarker of subclinical atheroscle(epmc).pdf DeepDyve Pubget Overpricing