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2015 ; 2015
(ä): 309601
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gab.com Text
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English Wikipedia
Prevention of Nausea and Vomiting in Patients Undergoing Oral Anticancer
Therapies for Solid Tumors
#MMPMID26421283
Costa AL
; Abreu C
; Pacheco TR
; Macedo D
; Sousa AR
; Pulido C
; Quintela A
; Costa L
Biomed Res Int
2015[]; 2015
(ä): 309601
PMID26421283
show ga
Chemotherapy-induced nausea and vomiting (CINV) is still a common and
debilitating side effect despite recent advances in its prevention and treatment.
The intrinsic emetogenicity of chemotherapy agents allowed grouping into four
risk groups (high, moderate, low, and minimal risk of emetogenicity). The
prevention of acute and delayed CINV for intravenous agents and one day regimens
is well studied, although, there are few data about management of CINV induced by
oral cytotoxic agents and targeted therapies, usually administered in extended
regimens of daily oral use. Until now treatment of nausea and vomiting caused by
oral antineoplastic agents remains largely empirical. The level of evidence of
prophylactic antiemetics recommended for these agents is low. There are
differences in the classification of emetogenic potential of oral antineoplastic
agents between the international guidelines and different recommendations for
prophylactic antiemetic regimens. Herein we review the evidence for antiemetic
regimens for the most used oral antineoplastic agents for solid tumors and
propose antiemetic regimens for high to moderate risk and low to minimal risk of
emetogenicity.