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Emerging Role of Myeloperoxidase in the Prognosis of Nephrotic Syndrome Patients
Before and After Steroid Therapy
#MMPMID26393116
Souparnika S
; D'Souza B
; D'Souza V
; Kumar S
; Manjrekar P
; Bairy M
; Parthasarathy R
; Kosuru S
J Clin Diagn Res
2015[Jul]; 9
(7
): BC01-4
PMID26393116
show ga
BACKGROUND: Myeloperoxidase (MPO) is a myelocyte derived iron containing enzyme
particularly involved in host defense by destroying foreign micro organisms
invading the body. Numerous evidences suggest that MPO is involved in the
pathogenesis of many inflammatory diseases, especially atherosclerosis. AIM:
Present study deals with the role of MPO in the renal function and progression of
disease in Nephrotic syndrome patients. STUDY DESIGN AND SETTINGS: Case- Control
Study carried out in Kasturba Medical College Hospital, Mangalore, India.
MATERIALS AND METHODS: Forty newly diagnosed Nephrotic syndrome cases, 40 age and
sex matched healthy controls and 15 subjects in Nephrotic syndrome remission,
were included in the study. Myeloperoxidase enzyme was assayed by 4 amino
antipyrine methods in all the subjects. Other renal parameters like urea,
creatinine, Blood Urea Nitrogen (BUN), BUN- Creatinine ratio (BUN/Cr) total
protein, albumin, globulin, albumin - globulin ratio (A/G ratio) and estimated
Glomerular Filtration Rate (eGFR) were also analysed. 24 hour urine
protein-creatinine ratio was estimated in Nephrotic syndrome cases and remission
group by turbidimetric assay. STATISTICAL ANALYSIS: Students paired t-test and
Wilcoxon Signed Rank test were used for the comparison of the data. Pearson and
Spearman analyses were used for correlation of the parameters. RESULTS: MPO
levels were found to be high in Nephrotic syndrome cases when compared to healthy
controls. Urea, creatinine, BUN, BUN/Cr ratio and eGFR were high in Nephrotic
syndrome cases while total protein, albumin, globulin and A/G ratio showed
decreased levels. MPO had a positive correlation with creatinine and urine
protein-creatinine ratio in Nephrotic syndrome. During remission, MPO levels
decreased significantly while total protein and albumin levels increased.
CONCLUSION: Myeloperoxidase enzyme is found to be elevated and it strongly
correlated with the severity of disease in Nephrotic syndrome. Further studies
can be done to use MPO as a therapeutic target in Nephrotic syndrome to
ameliorate the symptoms.
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