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10.1158/0008-5472.CAN-14-2887-T http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-14-2887-T C4572915!4572915 !26206560     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26206560 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Res 2015 ; 75 (18 ): 3699-705 Nephropedia Template TP {{tp|p=26206560 |t=2015. Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis |pdf=|usr=}}{{26206560 }} gab.com Text Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=26206560 #FOAvip Repurposing "old" drugs can facilitate rapid clinical translation but necessitates novel mechanistic insight. Warfarin, a vitamin K "antagonist" used clinically for the prevention of thrombosis for more than 50 years, has been shown to have anticancer effects. We hypothesized that the molecular mechanism underlying its antitumor activity is unrelated to its effect on coagulation, but is due to inhibition of the Axl receptor tyrosine kinase on tumor cells. Activation of Axl by its ligand Gas6, a vitamin K-dependent protein, is inhibited at doses of warfarin that do not affect coagulation. Here, we show that inhibiting Gas6-dependent Axl activation with low-dose warfarin, or with other tumor-specific Axl-targeting agents, blocks the progression and spread of pancreatic cancer. Warfarin also inhibited Axl-dependent tumor cell migration, invasiveness, and proliferation while increasing apoptosis and sensitivity to chemotherapy. We conclude that Gas6-induced Axl signaling is a critical driver of pancreatic cancer progression and its inhibition with low-dose warfarin or other Axl-targeting agents may improve outcome in patients with Axl-expressing tumors. Twit Text FOAVip Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=26206560 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26206560 #FOAvip English Wikipedia <ref>{{Cite pmid|26206560 }}</ref> Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis #MMPMID26206560 Kirane A ; Ludwig KF ; Sorrelle N ; Haaland G ; Sandal T ; Ranaweera R ; Toombs JE ; Wang M ; Dineen SP ; Micklem D ; Dellinger MT ; Lorens JB ; Brekken RA Cancer Res 2015[Sep]; 75 (18 ): 3699-705 PMID26206560 show ga Repurposing "old" drugs can facilitate rapid clinical translation but necessitates novel mechanistic insight. Warfarin, a vitamin K "antagonist" used clinically for the prevention of thrombosis for more than 50 years, has been shown to have anticancer effects. We hypothesized that the molecular mechanism underlying its antitumor activity is unrelated to its effect on coagulation, but is due to inhibition of the Axl receptor tyrosine kinase on tumor cells. Activation of Axl by its ligand Gas6, a vitamin K-dependent protein, is inhibited at doses of warfarin that do not affect coagulation. Here, we show that inhibiting Gas6-dependent Axl activation with low-dose warfarin, or with other tumor-specific Axl-targeting agents, blocks the progression and spread of pancreatic cancer. Warfarin also inhibited Axl-dependent tumor cell migration, invasiveness, and proliferation while increasing apoptosis and sensitivity to chemotherapy. We conclude that Gas6-induced Axl signaling is a critical driver of pancreatic cancer progression and its inhibition with low-dose warfarin or other Axl-targeting agents may improve outcome in patients with Axl-expressing tumors. |Animals [MESH] |Antineoplastic Combined Chemotherapy Protocols/therapeutic use [MESH] |Apoptosis/drug effects [MESH] |Axl Receptor Tyrosine Kinase [MESH] |Carcinoma, Pancreatic Ductal/*drug therapy/metabolism/pathology [MESH] |Cell Division/drug effects [MESH] |Cell Line, Tumor [MESH] |Cell Movement/drug effects [MESH] |Deoxycytidine/administration & dosage/analogs & derivatives/therapeutic use [MESH] |Disease Progression [MESH] |Drug Synergism [MESH] |Epithelial-Mesenchymal Transition/*drug effects [MESH] |Female [MESH] |Gemcitabine [MESH] |Gene Knockdown Techniques [MESH] |Humans [MESH] |Intercellular Signaling Peptides and Proteins/*physiology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Inbred NOD [MESH] |Mice, SCID [MESH] |Neoplasm Invasiveness [MESH] |Neoplasm Metastasis [MESH] |Neoplasm Proteins/antagonists & inhibitors/*physiology [MESH] |Pancreatic Neoplasms/*drug therapy/metabolism/pathology [MESH] |Proto-Oncogene Proteins/antagonists & inhibitors/genetics/*physiology [MESH] |RNA, Small Interfering/pharmacology [MESH] |Receptor Protein-Tyrosine Kinases/antagonists & inhibitors/genetics/*physiology [MESH] |Signal Transduction/drug effects [MESH] |Specific Pathogen-Free Organisms [MESH] |Warfarin/administration & dosage/*pharmacology/therapeutic use [MESH]Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic C(epmc).pdf DeepDyve Pubget Overpricing