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10.1038/cdd.2014.217 http://scihub22266oqcxt.onion/10.1038/cdd.2014.217 C4572867!4572867!25613377     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Differ 2015 ; 22 (7): 1192-202 Nephropedia Template TP {{tp|p=25613377|t=2015. CD95 promotes metastatic spread via Sck in pancreatic ductal adenocarcinoma |pdf=|usr=}}{{25613377}} gab.com Text CD95 promotes metastatic spread via Sck in pancreatic ductal adenocarcinoma JO: Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=25613377 #FOAvip Cancer stem cells (CSCs) have been implicated in the initiation and maintenance of tumour growth as well as metastasis. Recent reports link stemness to epithelial?mesenchymal transition (EMT) in cancer. However, there is still little knowledge about the molecular markers of those events. In silico analysis of RNA profiles of 36 pancreatic ductal adenocarcinomas (PDAC) reveals an association of the expression of CD95 with EMT and stemness that was validated in CSCs isolated from PDAC surgical specimens. CD95 expression was also higher in metastatic pancreatic cells than in primary PDAC. Pharmacological inhibition of CD95 activity reduced PDAC growth and metastasis in CSC-derived xenografts and in a murine syngeneic model. On the mechanistic level, Sck was identified as a novel molecule indispensable for CD95's induction of cell cycle progression. This study uncovers CD95 as a marker of EMT and stemness in PDAC. It also addresses the molecular mechanism by which CD95 drives tumour growth and opens tantalizing therapeutic possibilities in PDAC. Twit Text FOAVip CD95 promotes metastatic spread via Sck in pancreatic ductal adenocarcinoma ????Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=25613377 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25613377 #FOAvip English Wikipedia <ref>{{Cite pmid|25613377}}</ref> CD95 promotes metastatic spread via Sck in pancreatic ductal adenocarcinoma #MMPMID25613377 Teodorczyk M; Kleber S; Wollny D; Sefrin JP; Aykut B; Mateos A; Herhaus P; Sancho-Martinez I; Hill O; Gieffers C; Sykora J; Weichert W; Eisen C; Trumpp A; Sprick MR; Bergmann F; Welsch T; Martin-Villalba A Cell Death Differ 2015[Jul]; 22 (7): 1192-202 PMID25613377show ga Cancer stem cells (CSCs) have been implicated in the initiation and maintenance of tumour growth as well as metastasis. Recent reports link stemness to epithelial?mesenchymal transition (EMT) in cancer. However, there is still little knowledge about the molecular markers of those events. In silico analysis of RNA profiles of 36 pancreatic ductal adenocarcinomas (PDAC) reveals an association of the expression of CD95 with EMT and stemness that was validated in CSCs isolated from PDAC surgical specimens. CD95 expression was also higher in metastatic pancreatic cells than in primary PDAC. Pharmacological inhibition of CD95 activity reduced PDAC growth and metastasis in CSC-derived xenografts and in a murine syngeneic model. On the mechanistic level, Sck was identified as a novel molecule indispensable for CD95's induction of cell cycle progression. This study uncovers CD95 as a marker of EMT and stemness in PDAC. It also addresses the molecular mechanism by which CD95 drives tumour growth and opens tantalizing therapeutic possibilities in PDAC. äCD95 promotes metastatic spread via Sck in pancreatic ductal adenocarc(epmc).pdf DeepDyve Pubget Overpricing