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2015 ; 2015
(ä): 164635
Nephropedia Template TP
gab.com Text
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English Wikipedia
Role of MALAT1 as a Prognostic Factor for Survival in Various Cancers: A
Systematic Review of the Literature with Meta-Analysis
#MMPMID26420912
Wei Y
; Niu B
Dis Markers
2015[]; 2015
(ä): 164635
PMID26420912
show ga
OBJECTIVES: The expression of metastasis-associated lung adenocarcinoma
transcript 1 (MALAT1), a highly abundant and ubiquitously expressed long
noncoding RNA (lncRNA), influences clinical parameters and may have prognostic
value in cancer. This meta-analysis evaluated the prognostic role of MALAT1 in
various cancers. MATERIALS AND METHODS: Systematic literature searches of PubMed
and EMBASE databases were conducted for eligible studies of the prognostic role
of MALAT1 in cancer. Overall survival (OS), disease-specific survival (DSS), and
disease-free survival (DFS) were analyzed. Summary hazard ratios (HRs) and 95%
confidence intervals (95% CIs) were assessed to evaluate the influence of MALAT1
expression on patient prognosis. RESULTS: Nine studies with a total of 932
patients were included in the analysis. Elevated MALAT1 expression was
significantly correlated with poor OS (HR 2.02; 95% CI: 1.62-2.52; P < 0.001;
I(2) = 0%). Subgroup analysis indicated that tumor type, histology type,
ethnicity, and measurement technique did not affect the prognostic value of
MALAT1 for OS. The HR of elevated MALAT1 for DFS was 2.78 (95% CI: 1.87-4.15; P <
0.001; I(2) = 0%). CONCLUSIONS: Elevated MALAT1 expression is correlated with
poor OS in various types of cancer, suggesting that this gene is a prognostic
factor for different types of cancer.
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