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2015 ; 2015
(ä): 179528
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An Omics Perspective on Molecular Biomarkers for Diagnosis, Prognosis, and
Therapeutics of Cholangiocarcinoma
#MMPMID26421274
Seeree P
; Pearngam P
; Kumkate S
; Janvilisri T
Int J Genomics
2015[]; 2015
(ä): 179528
PMID26421274
show ga
Cholangiocarcinoma (CCA) is an aggressive biliary tract malignancy arising from
the epithelial bile duct. The lack of early diagnostic biomarkers as well as
therapeutic measures results in severe outcomes and poor prognosis. Thus,
effective early diagnostic, prognostic, and therapeutic biomarkers are required
to improve the prognosis and prolong survival rates in CCA patients. Recent
advancement in omics technologies combined with the integrative experimental and
clinical validations has provided an insight into the underlying mechanism of CCA
initiation and progression as well as clues towards novel biomarkers. This work
highlights the discovery and validation of molecular markers in CCA identified
through omics approaches. The possible roles of these molecules in various
cellular pathways, which render CCA carcinogenesis and progression, will also be
discussed. This paper can serve as a reference point for further investigations
to yield deeper understanding in the complex feature of this disease, potentially
leading to better approaches for diagnosis, prognosis, and therapeutics.